Hey Mary,


I would suggest observing your
stainer to ensure the proper drop zones are being performed and not just
dropping closest to the label. I used Dako for years and loved them but you do
have to make sure it dispenses properly from time to time. They use drop zones
unlike Ventana which uses a vortex type of mixing.



Good luck!



Thanks,



Timothy N. Higgins, HT (ASCP), QIHC



 

> Date: Mon, 23 Sep 2013 14:00:57 -0700 (PDT)
> From: Mary Benoit <[email protected]>
> Subject: [Histonet] edge effect on IHC
> To: "[email protected]"
>       <[email protected]>
> Message-ID:
>       <[email protected]>
> Content-Type: text/plain; charset=us-ascii
> 
> I have been aware of some "edge effect" on an occasional slide, but lately we 
> noticed the effect is showing up in the area of the slide that is farthest 
> from the labels. We use DAKO Link Autostainer and their pretreatment baths 
> for everything. One case in particular we stained a large melanoma met to 
> colon that was well fixed and processed that stained only the edge, however 
> when we sent block to Neogenomics reference lab, their slide stained evenly 
> over the entire tumor area. We both used a melanoma cocktail. Not sure what 
> is going on. Any suggestions?
> Thank you
> Mary F Benoit, MT(ASCP)
> The Pathology Laboratory
> 830 Bayou Pines Drive
> Lake Charles, LA 70601
> [email protected]
                                          
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