I believe the answer is "no", all other things being equal.

But if one of those "other things" is that the non-aligned operand spans 
cache lines whereas an aligned one would not, then the answer could be a 
huge "yes".

Things such as doubleword (or quadword) consistency could not be relied 
upon, depending on the degree of non-alignment.

Peter Relson
z/OS Core Technology Design

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