We are converting to z/VM 5.4 on our new z10. We have one set of z/Linux guests 
that still run RHEL 4.6. Does anyone know of any issues running RHEL 4.6 under  
z/VM 5.4?

No, that works just fine with the following exception:

If you are running with dedicated OSA ports, RHEL 4.6 has trouble with the 
OSAExpress3 adapters (doesn't know how to initialize them). Workaround (and 
general best practice): use VSWITCH to drive the real adapters and attach 
guests to the vswitch).

Also is there anything to watch out for running either z/VM 5.4 or z/Linux RHEL 
4.6 or 5.2 on a z10?

See above.  VM is fine. As usual, apply current service, but it should run fine.

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