Hello, did you ever find a solution to this?  We are having the same issues
on Windows Server 2003 IIS6 since updating our ASP app in Visual Studio.  It
will work for a while but then start happening again for no reason.  I have
to force a recompile (by touching web.config or something similar) then
deleting the temporary files for the specific app site in 
"C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files"
folder then it all works again... for a while.  This is very frustrating.

here is the error:

Event code: 3005
Event message: An unhandled exception has occurred.
Event time: 6/1/2013 6:50:21 PM
Event time (UTC): 6/2/2013 1:50:21 AM
Event ID: b7525287cfd8444ea87c8da91b07a10d Event sequence: 16 Event
occurrence: 1 Event detail code: 0

Process information:
    Process ID: 5500
    Process name: w3wp.exe
    Account name: NT AUTHORITY\NETWORK SERVICE

Exception information:
    Exception type: System.IO.FileLoadException
    Exception message: Could not load file or assembly 'itextsharp,
Version=5.0.2.0, Culture=neutral, PublicKeyToken=8354ae6d2174ddca' or one of
its dependencies. Access is denied.

    Thread account name: NT AUTHORITY\NETWORK SERVICE

Thread information:
    Thread ID: 1
    Thread account name: NT AUTHORITY\NETWORK SERVICE
    Is impersonating: False
    Stack trace:    at pdflib.PdfMerge.MergeFiles(String destinationFile,
String[] sourceFiles)
   at pdflib.PdfMerge.MergeFiles(String destinationFile, String[]
sourceFiles, String user, String domain, String password) in
c:\accounts\priority\dev\PPPAgentPortal\AgentPortal\pdflib\MergeFiles.cs:line
15
   at
AgentPortalNameSpace.postserveMyOrdersSA.buttonPrintDocuments_Click(Object
sender, EventArgs e) in
C:\accounts\priority\dev\PPPAgentPortal\AgentPortal\AgentPortal\postservePrintUpdateOrdersSA.aspx.vb:line
687
   at System.Web.UI.WebControls.Button.OnClick(EventArgs e)
   at System.Web.UI.WebControls.Button.RaisePostBackEvent(String
eventArgument)
   at
System.Web.UI.WebControls.Button.System.Web.UI.IPostBackEventHandler.RaisePostBackEvent(String
eventArgument)
   at System.Web.UI.Page.RaisePostBackEvent(IPostBackEventHandler
sourceControl, String eventArgument)
   at System.Web.UI.Page.RaisePostBackEvent(NameValueCollection postData)
   at System.Web.UI.Page.ProcessRequestMain(Boolean
includeStagesBeforeAsyncPoint, Boolean includeStagesAfterAsyncPoint)







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