On Thursday 13 July 2006 07:22, Bob Hanson wrote:
> Does anyone have experience implementing a Gasteiger charge calculation?
>
> I will try to take a look at
>
> J.Gasteiger and M.Marsili: Tetrahedron Vol. 36. , pp. 3219-3288 (1980)
>
> and see if there is any chance we can do this.

Miguel Rojas is working on this for the CDK. It is *not* trivial, i.e. the GM 
sigma are not overly difficult and the algorithm is published (the citation 
you give). This is not the case for the pi-charges (for delocalized electron 
systems), which are rather non-trivial, and the algorithm is not published in 
mainstream journals (there are actually two algorithms for the pi-charges). 
*And* one should not be using just sigma charges.

If you want to be able to calculate these charges, it's time to have a look at 
Bioclipse, which has the full Jmol inside (10.2 at this moment) with 
scripting language, and with access to the CDK library.

Egon

-- 
CUBIC
blog: http://chem-bla-ics.blogspot.com/


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