Large study finds COVID-19 is linked to a substantial drop in intelligence

by Eric W. Dolan July 24, 2021 in Cognitive Science, COVID-19
https://www.psypost.org/2021/07/large-study-finds-covid-19-is-linked-to-a-substantial-drop-in-intelligence-61577


People who have recovered from COVID-19 tend to score significantly lower on an 
intelligence test compared to those who have not contracted the virus, 
according to new research published in The Lancet journal EClinicalMedicine.

The findings suggest that the SARS-CoV-2 virus that causes COVID-19 can produce 
substantial reductions in cognitive ability, especially among those with more 
severe illness.

“By coincidence, the pandemic escalated in the United Kingdom in the middle of 
when I was collecting cognitive and mental health data at very large scale as 
part of the BBC2 Horizon collaboration the Great British Intelligence Test,” 
said lead researcher Adam Hampshire (@HampshireHub), an associate professor in 
the Computational, Cognitive and Clinical Neuroimaging Laboratory at Imperial 
College London.

“The test comprised a set of tasks designed to measure different dimensions of 
cognitive ability that had been designed for application in both citizen 
science and clinical research. A number of my colleagues contacted me in 
parallel to point out that this provided an opportunity to gather important 
data on how the pandemic and COVID-19 illness were affecting mental health and 
cognition.”

“I had been thinking the same thing and wanted to help out insofar as I could, 
so extended the study to include information about COVID-19 illness and the 
impact of the pandemic on daily life more generally,” Hampshire said.

For their study, Hampshire and his team analyzed data from 81,337 participants 
who completed the intelligence test between January and December 2020. Of the 
entire sample, 12,689 individuals reported that they had experienced COVID-19, 
with varying degrees of respiratory severity.

After controlling for factors such as age, sex, handedness, first language, 
education level, and other variables, the researchers found that those who had 
contracted COVID-19 tended to underperform on the intelligence test compared to 
those who had not contracted the virus.

The greatest deficits were observed on tasks requiring reasoning, planning and 
problem solving, which is in line “with reports of long-COVID, where ‘brain 
fog,’ trouble concentrating and difficulty finding the correct words are 
common,” the researchers said.

Previous research has also found that a large proportion of COVID-19 survivors 
are affected by neuropsychiatric and cognitive complications.

“We need to be careful as it looks like the virus could be affecting our 
cognition. We do not fully understand how, why, or for how long, but we 
urgently need to find out. In the meantime, don’t take unnecessary risks and do 
get vaccinated,” Hampshire told PsyPost.

The level of cognitive underperformance was also associated with the level of 
illness severity, with those who were hospitalized on a ventilator showing the 
greatest deficits. The observed deficit for COVID-19 patients who had been put 
on a ventilator equated to a 7-point drop in IQ. The deficit was even larger 
than the deficits observed for individuals who had previously suffered a stroke 
and who reported learning disabilities.

“I think it is fair to say that those of us who have been analyzing data such 
as this are somewhat nervous at the decision to let the pandemic run its course 
within the UK,” Hampshire said.

Although a small subset of 275 participants completed the intelligence test 
both before and after contracting COVID-19, the study mostly employed a 
cross-sectional methodology, limiting the ability to draw firm conclusions 
about cause and effect. But the large and socioeconomically diverse sample 
allowed the researchers to control for a wide variety of potentially cofounding 
variables, including pre-existing conditions.

“The main caveat is that we do not know what the mechanistic basis of the 
observed COVID-cognition association is. Nor do we know how long any impact on 
cognition might last. I am providing the assessment technology for use in a 
raft of studies that are now trying to answer these questions,” Hampshire said.

The Full Study is here: 
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00324-2/fulltext

The study, “Cognitive deficits in people who have recovered from COVID-19“, was 
authored by Adam Hampshire, William Trender, Samuel R. Chamberlain Amy E. 
Jolly, Jon E. Grant, Fiona Patrick, Ndaba Mazibuko, Steve C.R. Williams, Joseph 
M. Barnby, Peter Hellyer, and Mitul A. Mehta.

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