There is an issue related to this problem on github for tpm2-tss:
https://github.com/tpm2-software/tpm2-tss/issues/2691 (/dev/tpmrm0 was used)
The error did occur after abbout 200 signing operations when a second session 
was opened by a second process at the same time.
Kernel log:
[ 401.923826] tpm tpm0: tpm2_save_context: failed with a TPM error 0x0901
[  401.925049] tpm tpm0: A TPM error (459) occurred flushing context

Juergen


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