I don't have anything helpful to add.  Except maybe make sure your I/O
scheduler is deadline or noop.
https://access.redhat.com/solutions/5427

We've been fighting a very similar issue here and have never been able to
resolve it.

Our system:

3-host vSphere 5.5 cluster

Three SANs  (all RAID6) 
        2x Equallogic PS6100E 
                - 1 for storage of guest images
                - 1 for replication
        Equallogic PS6500E (42 7.2k 3-TB drives) 
                - data storage

We have a Linux NFS server with virtual disks are 8 12-TB VMDKs on the
6500E, joined via LVM into a single volume.

Average latency on some of the datastores is 100 ms, and we will
occasionally see up to 30-second latency in I/O (as reported by VMware).

https://imgur.com/a/mQM0H



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