The termination always occurs after it has started scanning my
working directory (which happens to be the Desktop for my
account, which again is an admin account).
Then I would suggest to test if it works if you change the working
directory to a folder with a simple name - the desktop can contain
problematic chars.




This suggestion definitely helped. Now, luaootfload-tool successfully rebuilds the FNDB. So, definitely a step in the right direction. My MWE (below) compiles, more or less. Turns out something is balking on unicode-math. If I try to compile the MWE as is, I get the following error:

))(load luc: $TEXMFCACHE/luatex-cache/generic/fonts/otf/xits-math.luc)(load luc:
 $TEXMFCACHE/luatex-cache/generic/fonts/otf/xits-mathbold.luc)
! Undefined control sequence.
\um_set_mathcode:nnn #1#2#3^^@-\Umathcode
\int_eval:n {#1}=\mathchar@type #2\c...
l.6 \setmathfont{XITS Math}

?

Basically, it chokes on unicode-math.




documentclass[11pt,letterpaper]{article}

\usepackage{fontspec}
\setmainfont{XITS}
\usepackage{unicode-math}
\setmathfont{XITS Math}

\begin{document}

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Praesent in tincidunt nulla. Donec quis laoreet est. Aenean vitae est felis, a venenatis magna. Mauris semper bibendum vulputate. Etiam bibendum quam ut erat rutrum consequat.

\begin{equation}
\frac{dN}{dt}=rN\left(1-\frac{N}{K}\right)
\end{equation}



\end{document}

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