> I have a huge newsletter list (no discussion) that no dedicated server can 
> handle, for mailman eats up the whole memory .. thus I divided it to several 
> lists on different servers .. and I do the subscription and cancellation 
> peocesses manually, I collect the requests on email addresses for 
> subscriptions and cancellations then process them manually ..

You might want to run Mailman with MySQL support. It's not official
but it works.
See http://trac.rezo.net/trac/rezo/browser/Mailman

I use it to run 400 lists including a 200K subs

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