Michael,
this seems related to a Microsoft known issue:
https://learn.microsoft.com/en-us/answers/questions/1388775/outlook-com-servers-tells-server-busy-please-try-a
 Regards
    Giovanni

Il 11 ottobre 2023 20:07:13 CEST, Michael Wise via mailop <[email protected]> 
ha scritto:
>
>That's volume throttling, not IP blocking.
>Did you recently bring a new block online, or ... someone sending out an 
>abnormally large volume of mail?
>If it's going out thru shared IPs, that could also be part of the problem, but 
>this is just speculation.
>
>Aloha,
>Michael.
>--
>Michael J Wise
>Microsoft Corporation| Spam Analysis
>"Your Spam Specimen Has Been Processed."
>Open a ticket for Hotmail<http://go.microsoft.com/fwlink/?LinkID=614866> ?
>
>From: mailop <[email protected]> On Behalf Of Andreas via mailop
>Sent: Wednesday, October 11, 2023 2:13 AM
>To: [email protected]
>Subject: [EXTERNAL] [mailop] outlook.com 421 try again later S77719
>
>
>Hello all,
>
>since a few hours we have problems with sending to Microsoft. We get hundreds 
>of messages like in the subject with the reference to S77719. Also colleagues 
>from other companies in germany are seeing the same in their logs. All mails 
>that are blocked here are from Microsoft customers, but they are redirected 
>through our servers.
>
>Trying to unblock the IP e.g. via https://sender.office.com/ shows that the 
>IPs are not blocked.
>
>Anybody have any idea?
>
>Thanks a lot
>Andreas
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