Louis Ignarro

Louis J. Ignarro


Born    May 31, 1941 (1941-05-31) (age 69)
Nationality     American
Fields  pharmacology
Institutions    UCLA School of Medicine, King Saud University
Known for       nitric oxide
Notable awards  Nobel Prize in Physiology or Medicine (1998)

Louis J. Ignarro (born May 31, 1941) is an Italian American
pharmacologist. He was corecipient of the 1998 Nobel Prize in
Physiology or Medicine with Robert F. Furchgott and Ferid Murad for
demonstrating the signaling properties of nitric oxide.
Louis Ignarro receives award from D. Wink at National Cancer Institute - NIH

He is currently professor of pharmacology at the UCLA School of
Medicine's department of molecular and medical pharmacology in Los
Angeles, which he joined in 1985. Before relocating to California, he
was a professor of pharmacology at Tulane University School of
Medicine, New Orleans, for 12 years. Ignarro has also previously
worked as a staff scientist, research department, for the
pharmaceutical division of CIBA-GEIGY Corporation in New York.

Ignarro has published numerous articles on his research. He received
the Basic Research Prize of the American Heart Association in 1998, in
recognition of his outstanding contributions to the advancement of
cardiovascular science. That same year, he was inducted into the
National Academy of Sciences and the following year, into the American
Academy of Arts and Sciences.

He is the founder of the Nitric Oxide Society, and founder and
editor-in-chief of Nitric Oxide Biology and Chemistry.[1] Ignarro
holds a B.S. in pharmacy, Columbia University, 1962, and a Ph.D. in
pharmacology, University of Minnesota, School of Medicine, 1966. He
also received a postdoctoral fellowship in chemical pharmacology from
National Institutes of Health in 1968. He is a member of the
scientific committee of Nicox, a French pharmaceutical company, a
member of the Board of Directors of Antibe Therapeutics,[2] a Canadian
drug discovery company, a member of the Board of Directors of
Operation USA, a non-profit organization, and a member of the
Nutritional Advisory Board for Herbalife, a for-profit nutrition and
weight-loss company.

    * 1 Awards and recognitions
    * 2 Early life
    * 3 Nitric oxide
    * 4 Herbalife relationship
    * 5 Publications
    * 6 See also
    * 7 Notes
    * 8 References
    * 9 External links

[edit] Awards and recognitions

    * Awarded a Nobel Prize in 1998.
    * By 1998 Ignarro was the winner of 11 consecutive Golden Apples,
the award UCLA medical students give to the year's best teacher.[3]
    * 2008 American Heart Association Distinguished Scientist.[4]

[edit] Early life

Born of Italian immigrants, Ignarro grew up near New York City, and
had a predilection for science from an early age, which led to a
bachelor's degree in pharmacy from Columbia University and a Ph.D. in
pharmacology from the University of Minnesota. His university studies
also concentrated in chemistry, enzymology and cardiovascular
physiology, and resulted in several published papers. His work
continued at the NIH in the fields he'd studied, collaborating with
many other scientists to discover regulatory mechanisms of the
cardiovascular system that would lead to his most famous work.
[edit] Nitric oxide

Nitric oxide, NO, not to be confused with nitrous oxide, N2O (a gas
used in anesthesia), is a colorless, odorless gas that is an important
signaling molecule in the body of mammals, including humans, but is
toxic at high doses. It is important in the chemical industry and is
also a toxic air pollutant produced by cigarette smoke, automobile
engines, and power plants. In 1994, the respected journal Science
declared nitric oxide as its "molecule of the year" for the exciting
discoveries surrounding its physiological signaling roles. Dr. Ignarro
has been prominent in advocating alternative medical uses including
the treatment of heart disease, shock, cancer, impotence, and
pulmonary hypertension. NO is now known to play a key role in many
biological functions including inflammation, blood flow regulation,
cell growth, smooth muscle relaxation, and preserving memory. Each
year, thousands of research papers are written about the molecule.[1]
Appropriate levels of NO production are important in protecting organs
from damage.
[edit] Herbalife relationship

Ignarro worked with Herbalife to develop Niteworks, a dietary
supplement designed to boost the body’s own production of nitric
oxide, and later became a member of the company’s Scientific Advisory
Board. Ignarro endorsed this product in exchange for a royalty
agreement reported to have earned his consulting firm over $1 million
in the first 12 months.

Ignarro also promoted Niteworks' ingredients in the Proceedings of the
National Academy of Sciences, where, as a member of the National
Academy of Sciences, he can submit papers without review, and
furthermore without disclosing his financial interest to the
publication. After Ignarro's ties to Herbalife were revealed, the
journal issued a correction to the article, citing Ignarro's
undisclosed "conflict of interest." UCLA conducted its own
investigation and determined that Ignarro did not act improperly as
all the research was done in Italy and no research funds came from
UCLA.[citation needed] Therefore, it was not legally necessary for him
to disclose anything. Ignarro presents a one-hour Herbalife
promotional video for Niteworks.
[edit] Publications

    * NO More Heart Disease: How Nitric Oxide Can Prevent - Even
Reverse - Heart Disease and Strokes. New York: St. Martin's Press
(2005). ISBN 0312335822.
    * Health Is Wealth: 10 Power Nutrients That Increase Your Odds Of
Living To 100. Health Value Publications (2009). ASIN: B002RS4388.

[edit] See also

    * Pharmacology
    * Pharmacy
    * Nitric Oxide

[edit] Notes

   1. ^ a b "Louis J. Ignarro Biography (1941-)". Free Health
Encyclopedia. http://www.faqs.org/health/bios/89/Louis-J-Ignarro.html.
Retrieved 2008-09-28.
   2. ^ Antibe Therapeutics
   3. ^ "Louis J. Ignarro". UCLA.
http://www.ucla.edu/about/nobelwinners/ignarro.html. Retrieved
2008-09-28. [dead link]
   4. ^ "Distinguished Scientist 2008". AHA.
Retrieved 2008-11-17.

[edit] References

    * UCLA Louis J. Ignarro, Medicine (1998)
    * "Nobel Prize Winner Didn't Disclose Herbalife Contract"
Bloomberg News report
    * Washington Post article "Nitric Oxide Now -- Ask Me How: Some
Find Nobel Laureate's Alliance With Supplement Marketer Hard to
Swallow", Washington Post, October 7, 2003
    * Louis Ignarro bio, Herbalife.com, cited March 17, 2008

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