There are 4 messages in this issue.
Topics in this digest:
1. Filmaka Online Film Competition
From: George Lessard
2. MEDICAL: VACCINATION : COUNTRIES: SOUTH AFRICA: First Large-Scale HI
From: David P. Dillard
3. MEDICAL: DISEASES: CANCER : MEDICAL ALTERNATIVE MEDICINE: HERBS AND
From: David P. Dillard
4. LAW: STATE AND LOCAL : INDUSTRY INDUSTRIES INDUSTRIAL: PHARMACEUTICA
From: David P. Dillard
Messages
________________________________________________________________________
1. Filmaka Online Film Competition
Posted by: "George Lessard" [EMAIL PROTECTED] themediamentor
Date: Thu Feb 8, 2007 3:21 pm ((PST))
---------------------------- Original Message ----------------------------
Subject: Film Competition
From: "Maria" <[EMAIL PROTECTED]>
Date: Thu, February 8, 2007 03:49
--------------------------------------------------------------------------
After the success of its first two contests, Filmaka has launched its third
contest 'Mistaken Identity'. Submissions are accepted till 27th February
2007.
www.filmaka.com <http://www.filmaka.com/>
<http://Filmaka.com> Filmaka.com Announces the Start of Contest #3!
February's topic is "Mistaken Identity," and all 1-3 minute films must be
uploaded by
midnight PST, February 27, 2007. The annual grand prize is a feature film
contract.
<http://Filmaka.com> Filmaka.com is a new online competition, juried by
award winning filmmakers including
Werner Herzog, Neil LaBute, Paul Schrader and Wim Wenders, and founded by
leading
independent producers and financiers. Filmmakers have a new chance to enter
each month, and submissions are accepted in 10 different languages.
Please visit www.filmaka.com to see past contest submissions, and for
complete rules, terms and conditions. Membership is free for full time
students: email [EMAIL PROTECTED] from your school issued
email account for more information.
Messages in this topic (1)
________________________________________________________________________
________________________________________________________________________
2. MEDICAL: VACCINATION : COUNTRIES: SOUTH AFRICA: First Large-Scale HI
Posted by: "David P. Dillard" [EMAIL PROTECTED] jwneastro
Date: Fri Feb 9, 2007 2:01 am ((PST))
Date: Thu, 8 Feb 2007 11:50:58 -0500
From: "NIH OLIB (NIH/OD)" <[EMAIL PROTECTED]>
To: [EMAIL PROTECTED]
Subject: FIRST LARGE-SCALE HIV VACCINE TRIAL IN SOUTH AFRICA OPENS
U.S. Department of Health and Human Services
NATIONAL INSTITUTES OF HEALTH
NIH News
National Institute of Allergy and Infectious Diseases (NIAID)
<http://www.niaid.nih.gov/>
FOR IMMEDIATE RELEASE: Thursday, February 8, 2007
CONTACT: NIAID News Office, Anne Oplinger, 301-402-1663, <e-mail:
[EMAIL PROTECTED]>
FIRST LARGE-SCALE HIV VACCINE TRIAL IN SOUTH AFRICA OPENS
A large-scale clinical trial of a candidate HIV vaccine -- which
previously showed promise in smaller studies in the United States and
elsewhere -- has now opened in South Africa. The study plans to enroll up
to 3,000 HIV-negative men and women, making it the largest African HIV
vaccine trial to date.
Conducted jointly by the South African AIDS Vaccine Initiative (SAAVI) and
the HIV Vaccine Trials Network (HVTN), the trial is supported by the
National Institute of Allergy and Infectious Diseases (NIAID), part of the
National Institutes of Health (NIH). The study vaccine, provided by Merck
& Co. Inc. (Whitehouse Station, NJ), contains copies of only three HIV
genes, not the entire virus, so it is impossible for a trial volunteer to
become infected from the vaccine.
"Our best hope of ending the AIDS epidemic is a safe and effective
vaccine," says NIH Director Elias A. Zerhouni, M.D. "To achieve that goal
requires the concerted effort of governments, scientists and private
industry as well as participation by well-informed volunteers."
"We applaud the South Africans for bringing this important trial to
fruition. This international partnership exemplifies the model of
collaboration needed to defeat HIV/AIDS," says NIAID Director Anthony S.
Fauci, M.D.
In South Africa the trial is called "Phambili" ("moving forward"). Also
known as HVTN 503, it is a Phase IIb "test-of-concept" trial, the first
such vaccine study in South Africa. This type of trial is designed to
provide preliminary information on vaccine efficacy and thus enable
researchers to decide whether or not to conduct a larger Phase III
efficacy trial that could lead to licensure.
In smaller trials, the vaccine was found to be safe and to stimulate
cellular immune responses against HIV in more than half of volunteers. To
date, more than 1,800 people have received at least one injection. Two
years ago, the first Phase IIb trial of the vaccine opened at sites in the
United States, Canada, South America, Australia and the Caribbean see
<http://www3.niaid.nih.gov/news/newsreleases/2005/mercktrial.htm>
areas where a subtype of HIV called clade B predominates. That trial is
ongoing.
As in that study, the main objectives of HVTN 503 are to determine whether
the candidate vaccine can prevent HIV infection or, in those who do become
infected, lower the level of HIV early on. Additionally, the new trial
will determine if the vaccine, which is based on clade B HIV, has the
potential to protect against the HIV clade C subtype prevalent in South
Africa. Immune responses in the first several hundred volunteers will be
assessed to ensure the vaccine induces promising immune responses in this
population against the clade C virus before proceeding to full enrollment.
Study volunteers must be healthy, sexually active, HIV-negative men and
women, ages 18 to 35 years old. Investigators will assign them at random
to receive either the test vaccine or an inactive placebo injection. The
trial is double-blind, meaning that neither the researchers nor the
volunteers know which a participant has received. All volunteers will be
regularly counseled about ways to reduce their risk of acquiring HIV, and
they will be given condoms. Access to care and treatment for sexually
transmitted infections will be provided, and because recent findings
indicate that medical circumcision can reduce the risk of HIV transmission
from women to men, access to medical circumcision will also be provided to
male participants who desire it.
In South Africa, the trial is led by Glenda Gray, MBBCH, FCPaeds (SA), of
the Perinatal HIV Research Unit, University of the Witwatersrand, based at
the Chris Hani Baragwanath Hospital in Soweto. James Kublin, M.D., M.P.H.,
of Fred Hutchinson Cancer Research Center, Seattle, serves as study
co-chair. The study is expected to recruit volunteers at five sites in
South Africa, located in Soweto, Cape Town, Klerksdorp, Medunsa and
Durban.
According to Dr. Gray, the study team has actively sought community
endorsement of and support for this clinical trial, both of which are
critical to its success. "Our communities here in South Africa are faced
with the burden of HIV on a daily basis, and the trial investigators and
study team have spent years developing a rapport with the community so
that together we can move forward in our quest to identify improved
approaches to prevent new HIV infections."
The test vaccine contains a weakened adenovirus that serves as a carrier
for three clade B HIV genes. Adenoviruses are among the main causes of
upper respiratory tract ailments such as the common cold. Because the
vaccine contains only three HIV genes housed in weakened adenoviruses,
study participants cannot become infected with HIV or get a respiratory
infection from the vaccine. The study aims to determine if the HIV genes
will induce a cellular immune response, producing immune cells that
recognize and kill cells infected with HIV.
The South African Medicines Control Council, the South African Department
of Agriculture and the U.S. Food and Drug Administration have reviewed the
trial and allowed the study to proceed. In order to conduct the trial,
sites also are required to obtain institutional ethics and biosafety
committee approvals.
NIAID is a component of the National Institutes of Health. NIAID supports
basic and applied research to prevent, diagnose and treat infectious
diseases such as HIV/AIDS and other sexually transmitted infections,
influenza, tuberculosis, malaria and illness from potential agents of
bioterrorism. NIAID also supports research on basic immunology,
transplantation and immune-related disorders, including autoimmune
diseases, asthma and allergies. News releases, fact sheets and other
NIAID-related materials are available on the NIAID Web site at
<http://www.niaid.nih.gov>.
The National Institutes of Health (NIH) -- The Nation's Medical Research
Agency -- includes 27 Institutes and Centers and is a component of the
U.S. Department of Health and Human Services. It is the primary federal
agency for conducting and supporting basic, clinical and translational
medical research, and it investigates the causes, treatments, and cures
for both common and rare diseases. For more information about NIH and its
programs, visit
<http://www.nih.gov>
###
--------------------------------
NIAID-Sponsored Vaccine Trial (HVTN 503) in the Republic of South Africa
Questions and Answers
<http://www3.niaid.nih.gov/news/QA/503qa.htm>
HIV Vaccine Trials Network (HVTN)
<http://www.hvtn.org>
South African AIDS Vaccine Initiative (SAAVI)
<http://www.saavi.org.za>
--------------------------------
This NIH News Release is available online at:
<http://www.nih.gov/news/pr/feb2007/niaid-08.htm>.
Sincerely,
David Dillard
Temple University
(215) 204 - 4584
[EMAIL PROTECTED]
Net-Gold
<http://groups.yahoo.com/group/net-gold>
<http://listserv.temple.edu/archives/net-gold.html>
General Internet & Print Resources
<http://library.temple.edu/articles/subject_guides/general.jsp>
<http://www.edu-cyberpg.com/ringleaders/davidd.html>
Digital Divide Network
<http://www.digitaldivide.net/profile/jwne>
Educator-Gold
<http://groups.yahoo.com/group/Educator-Gold/>
Messages in this topic (1)
________________________________________________________________________
________________________________________________________________________
3. MEDICAL: DISEASES: CANCER : MEDICAL ALTERNATIVE MEDICINE: HERBS AND
Posted by: "David P. Dillard" [EMAIL PROTECTED] jwneastro
Date: Fri Feb 9, 2007 3:17 am ((PST))
MEDICAL: DISEASES: CANCER :
MEDICAL ALTERNATIVE MEDICINE: HERBS AND BOTANICALS:
Memorial Sloan-Kettering Cancer Center:
Cancer Information:
About Herbs, Botanicals and Other Products
Memorial Sloan-Kettering Cancer Center:
Cancer Information:
About Herbs, Botanicals and Other Products
<http://www.mskcc.org/mskcc/html/11570.cfm>
About this Resource
<http://www.mskcc.org/mskcc/html/60783.cfm>
"This site provides objective information for oncologists and healthcare
professionals, including a clinical summary for each agent and details
about constituents, adverse effects, interactions, and potential benefits
or problems. Evaluations of alternative or unproved cancer therapies, as
well as products for sexual dysfunction are included. Our Integrative
Medicine Service staff, led by an oncology-trained pharmacist and
botanicals expert, manages this web site, which is continually updated as
new information becomes available.
A consumer version of each monograph also is available to help you deal
with the often confusing claims made for over-the-counter products and
regimens. It is important to ask your doctor or another qualified
professional about possible interactions with your specific medications
before taking any supplements."
Covered in This Database are These Herbals and Botanicals
#
714X
714-X (714X)
A
Acanthopanax Senticosus (Siberian Ginseng)
Active Hexose Correlated Compound (AHCC)
Acupressure (Acupuncture)
Acupuncture
AE-941 (Shark Cartilage)
Aesculus Hippocastanum (Horse Chestnut)
Agaricus
Agnus castus (Chasteberry)
AHCC
Alfalfa
Allium Sativum (Garlic)
Aloe Vera
Alpha-linolenic acid (Omega-3)
Alpha-Lipoic Acid
Amygdalin
Angelica Sinensis (Dong Quai)
Antineoplastons
Anvirzel (Oleandrin)
Aphanizomenon Flos Aquae (Blue-green Algae)
Arctic root (Rhodiola)
Arctium Majus (Burdock)
ArginMax
Arnica
Arnica Montana (Arnica)
Artemisia annua
artemisinin (Artemisia annua)
Ascorbic Acid (Vitamin C)
Ashwagandha
Astragalus
Avemar (Wheat germ extract)
Avlimil
Ayurveda
B
Baikal Skullcap (Scullcap)
Ban Lan Gen (Isatis Root)
Ban Zhi Lian (Scutellaria barbata)
Banlangen (Isatis Root)
Bee Pollen
Beta-Carotene
Beta-hydroxymethylbutyrate (HMB)
Bilberry Fruit
Biobran (MGN-3)
BioResonance Therapy
Biotin
Bitter Melon
Black Cohosh
Blue-green Algae
Borage
Boswellia
Bovine Cartilage
Bovine Colostrum
Bovine Immunologlobulin (Bovine Colostrum)
Bromelain
Buphenyl (Phenylbutyrate)
Bupleurum
Burdock
Burzynski Clinic (Antineoplastons)
Butchers Broom
C
CAAT
Calcium
Calcium Glucarate
Calendula
CanCell
Cantron (CanCell)
Capsaicin
Carnitine
Cartilade (Shark Cartilage)
Cascara
Catrix (Bovine Cartilage)
Cat's Claw
Cayenne
Cellect
Cellfood
Centella Asiatica (Gotu Kola)
Cesium Chloride
Chai Hu (Bupleurum)
Chamomile (German)
Chaparral
Chasteberry
Chili Pepper (Cayenne)
Chinese Asparagus
Chitosan
Cholesterol Spinach
Chromium
Chrysanthemum
Cimicifuga Racemosa (Black Cohosh)
CLA (Conjugated Linoleic Acid)
Coenzyme Q10
Coleus Forskohlii (Forskolin)
Colforsin (Forskolin)
Colloidal Silver
Comfrey
Coneflower (Echinacea)
Conjugated Linoleic Acid
Contreras Metabolic Therapy (Metabolic Therapies)
Controlled Amino Acid Therapy (CAAT)
Coptis Chinensis (Huanglian)
CoQ10 (Coenzyme Q10)
Coral Calcium
Cordyceps
Coriolus Versicolor
Couchgrass (Wheat grass)
Cranberry
Crataegus Monogyna (Hawthorn)
Creosate (Chaparral)
Curcuma Longa (Turmeric)
Curcumin (Turmeric)
D
Da Huang (Rhubarb)
Da Qing Ye (Isatis Leaf)
d-Alpha-tocopherol (Vitamin E)
Damiana
Dandelion
Dang Gui Long Hui Wan (Indirubin)
Dehydroepiandrosterone
Devil's Claw
d-Glucaric acid salt (Calcium Glucarate)
DHA (Omega-3)
DHEA (Dehydroepiandrosterone)
Di Bella Multitherapy
Dimethylglycine
Dimethylsulfoxide
Dismuzyme (Superoxide Dismutase)
D-limonene
DMSO (Dimethylsulfoxide)
Docosahexaenoic (Omega-3)
Dong Chong Xia Cao (Cordyceps)
Dong Quai
Dyer's woad (Isatis Root)
E
Echinacea
EGCG (Green Tea)
Eicosapentaenoic (Omega-3)
Electrodermal Testing (BioResonance Therapy)
Electromagnetic Field Therapy (Magnet Therapy)
Eleutherococcus Senticosus (Siberian Ginseng)
Ellagic acid
Energy Medicine (BioResonance Therapy)
Entelev (CanCell)
EPA (Omega-3)
Ephedra
Epimedium
Essiac
Eurixor (Mistletoe (European))
Evening Primrose Oil
F
Fat Trapper (Chitosan)
Fenugreek
Feverfew
Fish oil (Omega-3)
Flaxseed
Flor-Essence (Essiac)
Folate (Folic Acid)
Folic Acid
Forskolin
Fucoidan
G
Gan Cao (Licorice)
Ganoderma (Reishi Mushroom)
Garden Heliotrope (Valerian)
Garlic
Gaston Naessens 714X (714X)
GCP
Ge gen (Kudzu)
Genistein Combined Polysaccharide (GCP)
Germanium
Gerson Regimen
Ginger
Ginkgo
Ginsana (Ginseng (Asian))
Ginseng (American)
Ginseng (Asian)
Glehnia
GLN (Glutamine)
Glucosamine
Glutamine
Glyconutrients
Glycyrrhiza Glabra (Licorice)
Glycyrrhiza Uralensis (Licorice)
Goji (Lycium)
Goldenseal
Gonzalez Metabolic Therapy (Metabolic Therapies)
Gotu Kola
Grape Seed
Graviola
Green Tea
Grifola Frondosa (Maitake)
Guarana
Guggul
H
Haelan
Harpagophytum Procumbens (Devil's Claw)
Hawthorn
Helixor (Mistletoe (European))
Himematsutake (Agaricus)
HMB
Homeopathy
Hong Jing Tian (Rhodiola)
Hoodia
Horny Goat Weed (Epimedium)
Horse Chestnut
Hoxsey Herbal Therapy
Huang Chi (Astragalus)
Huang Qi (Astragalus)
Huang Qin (Scullcap)
Huanglian
Hydrastis Canadensis (Goldenseal)
Hydrazine Sulfate
Hydrocotyle Asiatica (Gotu Kola)
Hydrogen Peroxide Therapy (Oxygen Therapies)
Hypericum Perforatum (St. John's Wort)
Hyperoxygenated Water (Oxygen Therapies)
I
Ilex Paraguariensis (Mate)
Indian Frankincense (Boswellia)
Indian Saffron (Turmeric)
Indigo (Indirubin)
Indirubin
Indole-3-Carbinol
Inositol Hexaphosphate
Insulin Potentiation Therapy
IP-6 (Inositol Hexaphosphate)
Isatis Leaf
Isatis Root
Iscador (Mistletoe (European))
J top
Jiang Huang (Turmeric)
Ju Hua (Chrysanthemum)
Juice Plus
Juven (HMB)
Juzen-taiho-to (Shi Quan Da Bu Tang)
K
Karela (Bitter Melon)
Kava
Kelley Metabolic Therapy (Metabolic Therapies)
Kitosan (Chitosan)
Klimadynon (Black Cohosh)
Kombucha
Kudzu
Kwai (Garlic)
Kyolic (Garlic)
L
Laetrile (Amygdalin)
Lapacho (Pau D'arco)
Larrea Tridentate (Chaparral)
Lavender
Lentinan
Lentinula Edodes (Shiitake Mushroom)
L-Glutamine (Glutamine)
Licorice
Ligustrum lucidum
Limonene (D-limonene)
Linseed (Flaxseed)
Livingston-Wheeler Therapy
Lobelia
Lovastatin (Red Yeast Rice)
L-Theanine
Lutein
Lycium
Lycopene
M
Ma Huang (Ephedra)
Maca
Magnesium
Magnet Therapy
Maitake
Mangosteen
Manner Metabolic Therapy (Metabolic Therapies)
Marigold (Calendula)
Maroon Bush
Massage Therapy
Mate
Matricaria Recutita (Chamomile (German))
Meisoindigo (Indirubin)
Melaleuca Alternifolia (Tea Tree Oil)
Melatonin
Menofem (Black Cohosh)
Metabolic Therapies
MGN-3
MICOM
Milk Thistle
Mistletoe (European)
Mo Yao (Myrrh)
Momordica Charantia (Bitter Melon)
Morinda Citrifolia (Noni)
Morinda (Noni)
Mum (Chrysanthemum)
Music Therapy
Myrrh
N
NAC (N-Acetylcysteine)
N-Acetylcysteine
Naessens 714X (714X)
Neovastat (Shark Cartilage)
Nerium Oleander (Oleandrin)
Nettle
Niacin-bound Chromium (Chromium)
Noni
Nutritional Therapies (Metabolic Therapies)
O
Oenothera Biennis (Evening Primrose Oil)
Oleandrin
Olive Leaf
Omega-3
Oxygen Therapies
Oyster mushroom
Oyster Shell Calcium (Calcium)
Ozone Therapy (Oxygen Therapies)
P
P57 (Hoodia)
Panax ginseng (Ginseng (Asian))
Passionflower
Pau D'arco
Paullinia cupana (Guarana)
PC-SPES
Pectin
Pennyroyal
Perillyl Alcohol
Phenylbutyrate
Pine Bark Extract
Piper methysticum (Kava)
Poke Root (Pokeweed)
Pokeweed
Polydox
PolyMVA (Polydox)
Promensil (Red Clover)
Proteolytic enzymes
Protocel (CanCell)
PSK (Coriolus Versicolor)
Psoriacin (Bovine Cartilage)
Pu Gong Ying (Dandelion)
Pueraria (Kudzu)
Pycnogenol (Pine Bark Extract)
Pygeum
Pyroxidine (Vitamin B6)
Q
Qing Dai (Isatis Leaf)
Qing hao (Artemisia annua)
Quercetin
R
Radix Astragali (Astragalus)
Red Clover
Red Yeast Rice
Reishi Mushroom
Remifemin (Black Cohosh)
Resveratrol
Rheum Officinale (Rhubarb)
Rhodiola
Rhubarb
Rose root (Rhodiola)
Rumex Acetosella (Sheep Sorrel)
Ruscus Aculeatus (Butchers Broom)
S
S-adenosylmethionine (SAM-e)
Saiko (Bupleurum)
Saint John's Wort (St. John's Wort)
Salix Alba (Willow Bark)
Salvia Divinorum
SAM-e
Sassafras
Saw Palmetto
Schisandra
Scullcap
Scutellaria (Scullcap)
Scutellaria barbata
Sea Cucumber
Seasilver
Selenium
Serenoa Repens (Saw Palmetto)
Shan Zha (Hawthorn)
Shark Cartilage
Sheep Sorrel
Shi Quan Da Bu Tang
Shiitake Mushroom
Sho-saiko-to
Siberian Ginseng
Silver (Colloidal Silver)
Silybum Marianum (Milk Thistle)
Slippery Elm
SOD (Superoxide Dismutase)
Sodium Phenylbutyrate (Phenylbutyrate)
Soy (Haelan)
Soy
SPES (PC-SPES)
Sphaeria Sinensis (Cordyceps)
Spirulina (Blue-green Algae)
St. John's Wort
Stevia
Stillingia
Sun Farms Vegetable Soup
Sun Mushroom (Agaricus)
Sun Soup (Sun Farms Vegetable Soup)
Superoxide Dismutase
Symphytum Officinale (Comfrey)
T
Tabebuia Impetiginosa (Pau D'arco)
Tadenan (Pygeum)
Tai Chi
Tanacetum Parthenium (Feverfew)
Tea Fungus (Kombucha)
Tea Tree Oil
Theanine (L-Theanine)
Thioctic Acid (Alpha-Lipoic Acid)
Tian Men Dong (Chinese Asparagus)
Tian Xian
TJ-48 (Shi Quan Da Bu Tang)
Tocopherol (Vitamin E)
Trametes versicolor (Coriolus Versicolor)
TriButyrate (Phenylbutyrate)
Trifolium Pratense (Red Clover)
Trigonella (Fenugreek)
Turkey Rhubarb (Rhubarb)
Turmeric
Turnera aphrodisiaca (Damiana)
Turnera diffusa (Damiana)
U
Ubiquinone (Coenzyme Q10)
Ukrain
Ulmus Rubra (Slippery Elm)
Uncaria Tomentosa (Cat's Claw)
Urtica Dioica (Nettle)
V
Vaccinium Myrtillus (Bilberry Fruit)
Valerian
Viacreme
Viscum Album (Mistletoe (European))
Vitaltea (Essiac)
Vitamin A
Vitamin B17 (Amygdalin)
Vitamin B6
Vitamin C
Vitamin D
Vitamin E
Vitamin O
Vitex (Chasteberry)
W
Wheat germ extract
Wheat grass
Wild Yam
Willow Bark
Woad root (Isatis Root)
Wolf's Bane (Arnica)
Wu Wei Zi (Schisandra)
X
Xanthophyll (Lutein)
Y
Yerba Mate (Mate)
Yin Yang Huo (Epimedium)
Yohimbe
Yohimbine (Yohimbe)
Yun zhi (Coriolus Versicolor)
Z
Zestra
Zinc
Zingiber Officinale (Ginger)
Zostrix (Capsaicin)
Zyflamend
Content Sample:
Aloe Vera
Healthcare Professional Consumer
How It Works
Purported Uses
Research Evidence
Warnings
Do Not Take If
Side Effects
Scientific Name
Common Name
Clinical Summary
Purported uses
Constituents
Mechanism of Action
Warnings
Adverse Reactions
Herb-Drug Interactions
Literature Summary and Critique
References
Scientific Name
Aloe barbadensis, Aloe capensis
Common Name
Aloe gel, aloe leaf
Clinical Summary
Derived from the leaves of the plant. Topical administration of aloe vera
gel is generally safe. It may help reduce radiation-induced skin changes,
but clinical trial results are inconsistent (7) (8) (9). Some of the
components extracted from aloe vera have been shown to have anticancer
effects in vitro (11) (13) (14) (17) (16) and in animals (12) (15).
However, there is not enough evidence to support the use of aloe vera as
an anticancer drug in humans. Limited studies have demonstrated possible
efficacy in reducing ulcerative colitis (20) and in glycemic control in
diabetic patients (21). Aloe vera gel should not be confused with aloe
juice or aloe latex, both of which contain anthraquinone, a cathartic
laxative. Oral and parenteral administration of aloe vera should be
avoided due to potential toxicities and lack of clinical efficacy
demonstrated in humans. The FDA rules that aloe is not safe as a stimulant
laxative (10). Oral consumption of aloe vera has been linked to thyroid
dysfunction, acute hepatitis, and perioperative bleeding (22) (23) (24).
Cancer therapy using injections of acemannan, a mucopolysaccharide derived
from aloe vera, resulted in deaths of several patients (3).
Purported uses
Burns
Cold sores
Colitis
Diabetes
Dry Skin
Inflammation
Pain
Pruritus
Constituents
Mono- and polysaccharides
Tannins
Sterols
Organic acids
Enzymes
Saponins
Vitamins
Minerals
Glucomannan, acemannan
Emodin
Lipids: cholesterol, gamolenic acid
(4) (18)
Mechanism of Action
It is presently believed that some of the beneficial effects of aloe
result from inhibition of bradykinin by a contained carboxypeptidase. Aloe
is also believed to hinder the formation of thromboxane, the activity of
which is detrimental to burn wound healing (19). Laxative effect of aloe
juice and aloe latex is caused by anthraquinone glycosides aloin A and B
(18). Some studies have indicated that aloe vera may have anticancer
effects. Emodin, an extract of aloe vera, can inhibit cell proliferation
and induce apoptosis in human liver cancer cell lines through p53- and
p21-dependent pathway (11). Acemannan, a carbohydrate fraction derived
from aloe vera leaf, can stimulate cytokine production in mouse macrophage
cell line (17). This component also has immunomodulating activities by
inducing maturation of dendritic cells (13). Another in vitro study has
indicated aloeride, a polysaccharide obtained from aloe vera juice, as a
potent immunostimulator by increasing NF-kappa B activities (14). A
compound, di(2-ethylhexyl)phthalate (DEHP), isolated from aloe vera can
inhibit leukemic cells in vitro (16)..
Warnings Aloe vera gel should not be confused with aloe juice or aloe
latex, both of which contain anthraquinone, a cathartic laxative. Aloe
vera taken for internal use should be discouraged due to possible adverse
effects and inconclusive clinical data. Aloe vera injections for cancer
patients have resulted in several deaths. The FDA rules that aloe is not
safe as a stimulant laxative. (2) (3)
Adverse Reactions
Reported (oral): GI upset, nausea and vomiting, occasional rash
(dermatitis). Aloe vera supplements have been links to thyroid
dysfunction, acute hepatitis, and perioperative bleeding (22) (23) (24).
Toxicity: Seizures, potassium loss, and electrolyte abnormalities
(5)
Read more about this at the website above.
=======================================
Pertinent News Alerts from the FDA are also covered.
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Temple University
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4. LAW: STATE AND LOCAL : INDUSTRY INDUSTRIES INDUSTRIAL: PHARMACEUTICA
Posted by: "David P. Dillard" [EMAIL PROTECTED] jwneastro
Date: Fri Feb 9, 2007 7:14 am ((PST))
LAW: STATE AND LOCAL :
INDUSTRY INDUSTRIES INDUSTRIAL: PHARMACEUTICAL AND PHARMACY:
Merck Lobbies U.S. States to Require Cervical-Cancer Vaccine for
Schoolgirls
Merck Lobbies U.S. States to Require Cervical-Cancer Vaccine for
Schoolgirls
Tuesday, Jan. 30, 2007
Merck lobbies US states to require cervical-cancer vaccine for schoolgirls
By LIZ AUSTIN PETERSON Associated Press Writer
Associated Press
Findlaw News
<http://fsnews.findlaw.com/articles/ap/o/
51/01-31-2007/5cc40015c78acacf.html>
A shorter URL for the above link:
<http://tinyurl.com/38hgk8>
(AP) - AUSTIN, Texas-Merck & Co. is helping bankroll efforts to pass U.S.
state laws requiring girls as young as 11 or 12 to receive the drugmaker's
new vaccine against the sexually transmitted cervical-cancer virus.
Some conservatives and parents'-rights groups say such a requirement would
encourage premarital sex and interfere with the way they raise their
children, and they say Merck's push for such laws is underhanded. But the
company said its lobbying efforts have been above-board.
With at least 18 states debating whether to require Merck's Gardasil
vaccine for schoolgirls, Merck has funneled money through Women in
Government, an advocacy group made up of female state legislators around
the country.
A top official from Merck's vaccine division sits on Women in Government's
business council, and many of the bills around the country have been
introduced by members of Women in Government.
"Cervical cancer is of particular interest to our members because it
represents the first opportunity that we have to actually eliminate a
cancer," Women in Government President Susan Crosby said.
<snip>
But no state has yet to add Gardasil to the list of vaccinations
youngsters must have under law to be enrolled in school.
Merck spokeswoman Janet Skidmore would not say how much the company is
spending on lobbyists or how much it has donated to Women in Government.
Crosby also declined to specify how much the drug company gave.
But Skidmore said: "We disclosed the fact that we provide funding to this
organization. We're not in any way trying to obscure that."
----------------------------------------
Sincerely,
David Dillard
Temple University
(215) 204 - 4584
[EMAIL PROTECTED]
Net-Gold
<http://groups.yahoo.com/group/net-gold>
<http://listserv.temple.edu/archives/net-gold.html>
General Internet & Print Resources
<http://library.temple.edu/articles/subject_guides/general.jsp>
<http://www.learningis4everyone.org/>
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