> Actually have been using memcached for years and didn't have any problem, but 
> find a new memcached proxy called "twemproxy" and it said:
>
>  - Maintains persistent server connections.
>  - Keeps connection count on the backend caching servers low.
>
> Actually what wrong with memcached on the above two points? 
> Anyone have experience to share?

It's fine. It does use some amount of memory per connection. If you have a
huge number of connections, you may want to spread the memory usage around
a bit (by putting proxies on client hosts, or similar).

There's nothing inherent that would stop working at a large number of
connections.

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