I don't know exactly why poly-dT are more used in these kind of NMR studies (maybe they are cheaper because they are used to do RT-PCR). However, I know I would not choose poly-dG. They would be likely to form G-quadruplex at high concentration, which would be quite different from the expected single-stranded DNA.
Jonathan Perreault, post-doctoral fellow, Dr Ronald Breaker's lab Molecular, Cellular and Developmental Biology KBT Room 510 Yale University P.O. Box 208103 New Haven, CT 06520-8103 tel lab: (203) 432-6554 fax: (203) 432-6161
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