The wheel bundler runs setup.py on the bundler's machine, and then archive 
the result with static lists of dependencies. pip doesn't run setup.py at 
all when it installs a wheel (the .whl archive doesn't even contain that 
file); all it does is unarchive and copy the files.

Dynamic requirement resolution wouldn't work unless pip offers a mechanism 
for runtime hooks during installation, which doesn't seem to be on PyPA's 
roadmap.

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