Homicide ruling, documents detail death of Jackson
By THOMAS WATKINS and JUSTIN PRITCHARD

LOS ANGELES – The Los Angeles County coroner's finding that the death
of Michael Jackson was a homicide could mean criminal charges for his
doctor, who told investigators he administered a mix of powerful drugs
to treat the pop star's insomnia hours before his death.

The homicide ruling was based on forensic tests that found the
anesthetic propofol combined with at least two sedatives to kill
Jackson, a law enforcement official told The Associated Press,
speaking on condition of anonymity because the findings have not been
publicly released.

The finding does not necessarily mean a crime was committed. But it
does help prosecutors if they decide to file criminal charges against
Dr. Conrad Murray, the Las Vegas cardiologist who was caring for
Jackson when he died June 25 in a rented Los Angeles mansion.

"It is an easier prosecution when the medical examiner calls it a
homicide," said Dr. Michael Baden, the former chief medical examiner
in New York City, who is not involved in the Jackson investigation.

Through his lawyer, Murray has said he administered nothing that
should have killed Jackson.

Murray told investigators that at the time of Jackson's death, he had
been trying to wean the entertainer off propofol. The doctor said he'd
been treating Jackson for insomnia for about six weeks with 50
milligrams of the drug every night via an intravenous drip, a search
warrant affidavit said.

Murray said he feared Jackson was becoming addicted to the anesthetic,
which is supposed to be used only in hospitals and other advanced
medical settings.

Murray told police he was present when another Las Vegas
anesthesiologist, Dr. David Adams, sedated Jackson with propofol at an
unnamed cosmetologist's office "sometime between March and April of
this year," according to the affidavit.

It was about the time Jackson requested that Murray become his
personal physician for a European tour, the affidavit said.

A woman at Adams' office in Las Vegas referred calls Tuesday to his
lawyer, Liborius Agwara, who did not immediately respond to messages
seeking comment.

Nevada State Board of Osteopathic Medicine records show Adams has been
licensed in the state of Nevada since 2002, and there are no reports
of malpractice and no disciplinary issues against him. Ongoing
investigations are confidential unless a licensee is named in a formal
administrative complaint.

The affidavit was unsealed in Houston, where Los Angeles police took
materials from one of Murray's clinics last month as part of their
manslaughter investigation. Manslaughter is homicide without malice or
premeditation.

The affidavit says Murray told detectives that two days before
Jackson's death, he had lowered the propofol dose to 25 milligrams and
added the sedatives lorazepam and midazolam, a combination that
succeeded in helping the pop star sleep. The next day, Murray said, he
cut off the propofol and Jackson fell asleep with just the two
sedatives.

But on June 25, Murray said, he tried unsuccessfully to make Jackson
sleep with a series of drugs that included a 10-milligram tablet of
Valium and repeated injections of two milligrams of lorazepam and two
milligrams of midazolam.

When the combination didn't work, he said he gave in to Jackson's
"repeated demands/requests" for propofol, which the singer called his
"milk," according to the affidavit.

Around 10:40 a.m., Murray administered 25 milligrams of the white-
colored liquid — a relatively small dose — and finally Jackson fell
asleep.

Murray remained with the sedated Jackson for about 10 minutes then
left for the bathroom, the affidavit said. Less than two minutes
later, Murray returned and found Jackson had stopped breathing.

Cell phone records show three separate calls from Murray's phone
between 11:18 a.m. and 12:05 p.m., the affidavit said. Murray said one
call was to Jackson's personal assistant, Michael Amir Williams,
saying he needed help to deal with an emergency in Jackson's top-floor
bedroom. It's not clear who else received calls. Murray told
authorities he was administering CPR during that time.

In a statement posted late Monday on his firm's Web site, Murray's
attorney Edward Chernoff questioned the timeline as depicted in the
affidavit, calling it "police theory."

"Dr. Murray simply never told investigators that he found Michael
Jackson at 11:00 a.m. not breathing," Chernoff said. He declined to
comment on the homicide ruling, saying, "We will be happy to address
the coroner's report when it is officially released."

The coroner's office has withheld its autopsy findings, citing a
request from police to wait until their investigation is complete.

It is no surprise that such a combination of medications could kill
someone, said Dr. David Zvara, anesthesia chairman at the University
of North Carolina at Chapel Hill.

"All those drugs act in synergy with each other," Zvara said. Adding
propofol on top of the other sedatives could have "tipped the balance"
by depressing Jackson's breathing and ultimately stopping his heart,
he said.

The 25 milligrams of propofol "is not a whopping amount," said Lee
Cantrell, director of the San Diego division of the California Poison
Control System. It was the cocktail of the other sedatives, known as
benzodiazepines, that "may have been the trigger that pushed him over
the edge," Cantrell said.

"This is horrible polypharmacy," he said, referring to the interaction
among the various drugs. "No one will treat an insomniac like this."

The affidavit, signed by a judge July 20, said the coroner's office
chief medical examiner told police his review of preliminary
toxicology results showed "lethal levels of propofol."

Murray didn't tell paramedics or doctors at the UCLA hospital where
Jackson was rushed about any drugs he administered other than
lorazepam and flumazenil, a "rescue drug" to counteract problems from
too much lorazepam, according to the affidavit.

It was only during a subsequent interview with Los Angeles police
detectives that Murray gave a fuller accounting of the events leading
up to the 911 call, the document said.

The coroner's office said Tuesday it had no comment on the case. A
spokeswoman for the Los Angeles District Attorney's said no case had
been presented so the office had nothing to comment on.

The line between safe and dangerous doses of propofol is thin, and
according to the drug's guidelines a trained professional must always
stay bedside. Home use of propofol is virtually unheard of — safe
administration requires both a specially trained anesthesiologist and
an array of lifesaving equipment. Murray was trained as a heart
doctor, not a pain and sedation specialist.

A patient's weight determines the correct dose of a drug like
propofol. Jackson was thin and reportedly exhausted from the rigors of
rehearsing for a series of summer comeback concerts.

The hazards of getting the dose right is one reason propofol is
supposed to be given only by specially trained professionals in a
setting where rescue equipment and personnel are immediately
available. When the drug is used for surgical anesthesia, doctors
typically give one dose to put the patient under and then a lighter
dose to maintain anesthesia.

Authorities said in the affidavit that federal Drug Enforcement
Administration agents had been unable to find records tying Murray to
the acquisition of propofol. By Aug. 11, however, investigators had
served a search warrant at a Las Vegas pharmacy and uncovered evidence
showing Murray legally purchased the propofol he gave Jackson on the
day he died.

Jackson's family members released a statement Monday, saying they have
"full confidence" in the legal process and the efforts of
investigators. It concludes: "The family looks forward to the day that
justice can be served."

___

Contributing to this report were AP Medical Writer Marilynn Marchione
in Milwaukee and Associated Press Writers Alicia Chang in Los Angeles,
Michael Gracyzk in Houston and Ken Ritter in Las Vegas.
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