Great!  Thank you for the super fast response!  I'll give it a whirl today.

On Tuesday, January 23, 2018 at 7:27:33 AM UTC-5, Graham Dumpleton wrote:
>
> FWIW. I have created:
>
> * https://github.com/GrahamDumpleton/mod_wsgi/issues/260
>
> to have it use value of $TMPDIR rather than /tmp. On MacOS that should 
> result in special directory down under /var/tmp being used and cron 
> shouldn't delete it.
>
> Graham
>
> On 23 Jan 2018, at 8:21 pm, Graham Dumpleton <[email protected] 
> <javascript:>> wrote:
>
> Use the --server-root option to have the files generated by 
> mod_wsgi-express, generated into a directory other than under /tmp.
>
> On some system setups, cron jobs exist that will delete files under /tmp 
> that are older than a certain date. This can cause the failure.
>
> Graham
>
> On 23 Jan 2018, at 8:17 pm, Teemu Korpijaakko <[email protected] 
> <javascript:>> wrote:
>
> We're having an issue with a Flask application running under 
> mod_wsgi-express on a Mac mini.  2 of them actually and they both have the 
> same issue.  The application runs fine for a while (a week or a few days) 
> and then users see a Forbidden message.  We then have to kill apache and 
> restart it using flask/bin/mod_wsgi-express start-server --port 5000 
> ./wsgi.py &.  It starts up fine and runs until the next failure.  The 
> error_log looks like this prior to failure:
>
>
>
> [Tue Jan 23 06:56:02.435292 2018] [access_compat:error] [pid 7740] [client 
> 192.168.100.5:57279] AH01797: client denied by server configuration: 
> /tmp/mod_wsgi-localhost:5000:501/htdocs 
>
> [Tue Jan 23 06:56:28.573308 2018] [access_compat:error] [pid 7609] [client 
> 192.168.100.5:57280] AH01797: client denied by server configuration: 
> /tmp/mod_wsgi-localhost:5000:501/htdocs 
>
> [Tue Jan 23 06:57:13.220948 2018] [access_compat:error] [pid 7740] [client 
> 192.168.100.5:57282] AH01797: client denied by server configuration: 
> /tmp/mod_wsgi-localhost:5000:501/htdocs 
>
> [Tue Jan 23 06:57:15.918491 2018] [access_compat:error] [pid 7609] [client 
> 192.168.100.5:57283] AH01797: client denied by server configuration: 
> /tmp/mod_wsgi-localhost:5000:501/htdocs 
>
> [Tue Jan 23 06:57:35.765019 2018] [mpm_prefork:notice] [pid 5343] AH00169: 
> caught SIGTERM, shutting down 
>
> [Tue Jan 23 06:57:38.498538 2018] [mpm_prefork:notice] [pid 7753] AH00163: 
> Apache/2.4.18 (Unix) mod_wsgi/4.5.5 Python/2.7.10 configured -- resuming 
> normal operations 
>
> [Tue Jan 23 06:57:38.498826 2018] [core:notice] [pid 7753] AH00094: 
> Command line: 'httpd (mod_wsgi-express) -f 
> /tmp/mod_wsgi-localhost:5000:501/httpd.conf -D FOREGROUND'
>
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