Sergio, I see the problem.
As others have said, your PC board layout may be correct for your net list, but it is completely wrong for a switching power supply.
The Nixie power supply design by Nick DeSmith is a good one. Copy it exactly.
When doing a PC board layout, the first thing to do is to move around all the parts so that the connecting lines are as short as possible. This takes a lot of time. I will typically spend a day moving the parts around to get a nice placement. After I do that, then the wiring part of the job only takes an hour.
Also, be sure to use heavy traces for power. Those bypass capacitors next to the ICs are essential too.
A PC board layout that looks pretty is more likely to work well than one with the traces spread nilly-willy all over the board.
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