>>> I think you can get by with 4 control signals to the HV5522, so a quad 
>>> op-amp will work as a level-shifter.

>> That's using an op-amp as a comparator.  This is generally not a good idea.  
>> Use a comparator instead.
> 
> In what way is using an op-amp comparator not using a comparator?

An op-amp and a comparator are two different (but related things).  An op-amp 
is designed to be operated closed-loop, with
its output somewhere between the supply rails.  A comparator is designed to be 
operated open-loop, with its output intended
to be at one rail or the other, switching rapidly between them.

While it is possible to use an op-amp as a comparator, it's not a good idea.  
Some op-amps can latch up when used this way,
or take significant time to recover after being driven all the way to a rail.  
It comes under the heading of using a device outside
of its data sheet ratings.

So when you ask "In what way is using an op-amp comparator not using a 
comparator?" I'm confused, as there is no such
animal as an "op-amp comparator", as far as I know.  Op-amps and comparators 
are two different (but related) things.
They both have positive and negative inputs and an output, and generally use 
the same triangular circuit symbol, but their
implementation and use are different.

For a detailed explanation of op-amps versus comparators, see this app note:
http://www.analog.com/media/en/technical-documentation/application-notes/AN-849.pdf

- John

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