A quick update to draw a line under this topic: since the last post some 
time ago, I've had no more failures, even on the non-multiplexed clocks. 
Here are my observations:

In general, IN-1 *are* more sensitive to misuse, and will bridge over 
between digits (1 and 6, 4 and 8) if not driven within their parameters. 
Presumably this is because of the lack of mercury doping, which also gives 
them their warm glow

If run in multiplexed mode, there does not appear to be a large problem. 
You should still respect the current limits, but it is possible to 
moderately over-drive the tubes with no ill effects. My oldest multiplexed 
IN-1 clock is still looking great after a couple of years of continuous use 
and no special precautions.

If run in direct mode, you have to be more careful with the current limit. 
I had repeated failures until I really measured the current and adjusted it 
to be in-spec (3mA). Even with direct drive I still pulse the current, but 
that is because my design easily allows for it, and I use ambient light 
dimming.

IN-1s *do need more care* than other tubes, but if you are careful with the 
current or use multiplexing, you should be OK.

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