For direct-drive of true nixies (non-segmented), I'm really happy with the 
design of my last clock. The cathodes are driven by a HV5532, and the anode 
has an adjustable current-regulator. Having the HV driver and the 
deserializer+latch in a single device is really handy. The only drawback to 
this device is that it's spec'd to run at 12V, so a level shifter is needed.

I have 2 different clocks using cathode-current regulation and I'm not 
seeing any problems with the circuit.

My first nixie clocks use unregulated drivers, but the anode supply is 
rather high (+340V) so variations in the tube's voltage-drop over it's 
lifetime have minimal impact on the current. That approach wastes a lot of 
energy (about 330mW per tube * 6 tubes/clock * 4 clocks running 24/7 
=70KwHr per year....), which is why I switched to current-regulators and 
lowered the anode supply to around 190V.

I hate to think how many kilowatt hours each year are wasted running my 6 
nixie clocks; that adds up to 53 tubes.....

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