I'm always paranoid about ESD, so I would suggest removing tubes before 
testing them with something that generates an e-field. Most, but not all, 
CMOS devices have limited ESD protection that is intended to protect the 
device during assembly; certainly not for deliberately-induced charge.

If out-of-circuit testing is not possible, then I would leave the clock 
energized and try touching against the tube's envelope. I believe that a 
powered-on device will shunt induced charge better than when unpowered. I 
think the risk of ESD-induced latchup  in the driver IC is minimal, because 
you wont be touching the circuit with a charged device, only the tube's 
envelope.

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