Direct drive or multiplexing - I would vote for direct drive. It is just 
simpler to control, as you need to set the GPIOs only once a second.
As far as I 've heard, controlling GPIO of a RPI is problematic, so you 
could use shift registers or I2C I/O expanders. With those you aren't 
really limited when it comes to amount of pins used.
The main advantage of multiplexing is less pins needed to control the 
tubes. With 6 tubes you need at least 60 outputs for direct drive and only 
16 for multiplexing.
Also, I do not know if RPI has timers working in same way as they work on 
standard microcontrollers, and executing the multiplexing routine is 
critical for non-flickering display.
Both displays can achieve same brightness. In real designs, multiplexed 
displays used higher current per tube to achieve an average current similar 
to direct driven tube. Most hobbyists tend to use lower currents in hope of 
increasing lifespan of a tube, however I'd advise to stay over the minimum 
current, if it is provided in the datasheet.

Power supply - the problems with IN-18 and infamous blue spots do not come 
from the power supply voltage itself. 180V is perfectly fine as long as you 
use decend high voltage cathode switchers (Supertex HV shift registers, 
MMBTA42s or other 200+V transistors). *Stay away from 74141 *or their 
soviet counterpart. These devices are poorly constructed, consume alot of 
power compared to modern ICs and are old - no one guarantees that they will 
work after so many years. Poor transistor technology from these years is 
the reason why people are having troubles with blue spots.
I do not know how the voltage can decrease life of the tube - you still 
need a current limiting resistor. Tubes die faster from incorrect current 
(peak and average).
RPI doesn't have its own analog to digital converter. This means you cannot 
directly check the voltage at the output without an external ADC. I suggest 
using a standalone power supply unit, preferably with an Enable pin, so you 
could make some power saving routines.

Other big nixies - within similar price range, Z566M/Z5660M. Very 
beauftiful, with thin and sharp digits. Durable, with long life time. Still 
avaible on the market in reasonable amounts, so getting a spare tube 
shouldn't be a big problem*.  Datasheet has clear information about minimum 
average current, maximum average current and peak current per cathode. It 
also uses a more popular socket. 

*of course, no tube will be ever as avaible as russian tubes - Soviets 
produced alot more than needed ;) 


BTW. I've started my journey with ESP8266 very recently and I'm a newbie to 
the NTP topic. How often can I check the time at a server to be not 
considered a spammer? Is once per hour okay?

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