Dear NM group, I am running my own DES defined PD model and Nonmem generates the following warning. What does this warning mean and does it have any implications even if I get successful minimization.
(WARNING 48) DES-DEFINED ITEMS ARE COMPUTED ONLY WHEN EVENT TIME INCREASES. E.G., DISPLAYED VALUES ASSOCIATED WITH THE FIRST EVENT RECORD OF AN INDIVIDUAL RECORD ARE COMPUTED WITH (WITH LAST ADVANCE TO) AN EVENT TIME OF THE PRIOR INDIVIDUAL RECORD. Kindly advice...MNS
