Mahesh, This is just a warning that the table output of values computed in $DES is not exactly what you would expect. For mysterious reasons NONMEM is unable to remember the values of $DES variables computed at the first event for an individual. The table output shows the value from the last record of the previous individual for these $DES variables.
There is rarely any good reason to look at the values of variables in $DES. It should always be possible to compute the same value in $ERROR and then you will get consistent values for each individual. Nick > "Samtani, Mahesh [PRDUS]" wrote: > > Dear NM group, > I am running my own DES defined PD model and Nonmem generates the following > warning. What does this warning mean and does it have any implications even > if I get successful minimization. > > (WARNING 48) DES-DEFINED ITEMS ARE COMPUTED ONLY WHEN EVENT TIME > INCREASES. E.G., DISPLAYED VALUES ASSOCIATED WITH THE FIRST EVENT RECORD > OF AN INDIVIDUAL RECORD ARE COMPUTED WITH (WITH LAST ADVANCE TO) AN EVENT > TIME OF THE PRIOR INDIVIDUAL RECORD. > > Kindly advice...MNS -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/
