I suggest that you look at NONMEM Users Guide VIII, EXOGENOUS SUPPLEMENTATION EXAMPLE >From the example: A fragment of the data follows. Record 1 specifies the SS infusion for the pre-existing drug, which ends at time 0. Record 2 gives the baseline observation. Note also the use of R1 in the $PK block.
On Wed, 26 Sep 2007 16:14:36 -0400 (EDT), "Ganesh Mugundu" <[EMAIL PROTECTED]> said: > Dear all, > > I am trying to develop a model for a drug that was administered in > multiple doses to outpatient paediatric patients. Blood samples were > collected after the last dose and most of the patients have a > concentration at 0hr time point. The drug follows a one compartment model > and has a short halflife. I am not sure how to incorporate the previous > dose to reflect the 0hr concentration. I would highly appreciate if you > could help me in setting up the data file . > > Data of a patient after 9 doses of the drug at 6 hourly interval. > > ID TIME DV AMT DOSE MDV ADDL II > 1 0 0 179.4 179.4 1 9 6 > 1 0 0.5 0 179.4 0 0 0 > 1 0.35 10.1 0 179.4 0 0 0 > 1 0.68 12.1 0 179.4 0 0 0 > 1 1 12.2 0 179.4 0 0 0 > 1 1.5 8.9 0 179.4 0 0 0 > 1 2 7.2 0 179.4 0 0 0 > 1 4 3.6 0 179.4 0 0 0 > 1 6 2.1 0 179.4 0 0 0 > 1 8 2.2 0 179.4 0 0 0 > > Thanks > Ganesh Mugundu > -- Alison Boeckmann [EMAIL PROTECTED]
