Dear Howard, In addition to the paper which Ganesh sent you, this paper will probably be helpful:
Hatanaka T, Honda S, Sasaki S, Katayama K, Koizumi T. Pharmacokinetic and pharmacodynamic evaluation for tissue-selective inhibition of cholesterol synthesis by pravastatin. J Pharmacokinet Biopharm. 1998 Jun;26(3):329-47. Best regards Juergen -----Ursprüngliche Nachricht----- Von: "Howard Lee" <[EMAIL PROTECTED]> Gesendet: 23.04.08 03:58:16 An: "'Ganesh Mugundu'" <[EMAIL PROTECTED]> CC: <[email protected]> Betreff: RE: [NMusers] Population PK Analysis of Simvastatin Dear Ganesh, Thank you for your reply and inforamtion. In the said paper, however, the simvastatin PK was not modeled. Instead, dose-PD relationship was explored. Thank you again anyway. More inputs from others are welcome. Howard -----Original Message----- From: Ganesh Mugundu [mailto:[EMAIL PROTECTED] Sent: Tuesday, April 22, 2008 9:47 PM To: Howard Lee; [email protected] Subject: Re: [NMusers] Population PK Analysis of Simvastatin I am not sure if this reference is helpful Faltaos DW, Urien S, Carreau V, Chauvenet M, Hulot JS, Giral P, Bruckert E, Lechat P. Use of an indirect effect model to describe the LDL cholesterol-lowering effect by statins in hypercholesterolaemic patients. Fundam Clin Pharmacol. 2006 Jun;20(3):321-30. Ganesh --------------------------------------- Ganesh M Mugundu Graduate Student College of Pharmacy University of Cincinnati Cell: 513 417 4847 BLOG: http://pk-pd.blogspot.com/ WebPage: www.geocities.com/ganaish If you want to get somewhere, you have to know where you want to go and how to get there. Then NEVER, NEVER, NEVER GIVE UP." Norman Vincent Peale
