Yes, it is fixed in Nonmem VII. Katya -------------------------- Ekaterina Gibiansky Senior Director, PKPD, Modeling & Simulation ICON Development Solutions [email protected]
-----Original Message----- From: [email protected] [mailto:[email protected]] On Behalf Of Nick Holford Sent: Friday, February 06, 2009 6:39 AM To: [email protected] Subject: Re: [NMusers] simulation question Hi, I dont understand why this wasn't fixed in NONMEM VI. It was a well known bug in NONMEM V and has caused lots of grief for users. I hope the NONMEM VII developers have got this high on their list of NONMEM bugs that need to be fixed. Nick >> Dear users, >> I am trying to compare several specific PK/PD study designs by: >> -- run 200 simulations with the final model (develope from original >> dataset) >> -- fit the final model to the 200 simulated dataset >> To achieve above, I used $SIM SUBPROB=200 option >> however, nonmem would completely stop after running >> into estimation problem at one specific simulation/estimation cycles, >> for some designs it stop even before 10th iterations. >> Is there anyway nonmem could continue go on? >> Or, does someone know alternative way to achieve the goal? >> thanks >> >> >> > -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand [email protected] tel:+64(9)923-6730 fax:+64(9)373-7090 http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
