Dear Ethan, Have you tried removing the $ESTIMATION step and replace all values with your final estimations? What does your result file say after termination?
Sincerely Rob >>> Sebastian Ueckert <[email protected]> 02/06/09 10:51 >>> On Thu, Feb 5, 2009 at 11:18 PM, Ethan Wu <[email protected]> wrote: > Dear users, > I am trying to compare several specific PK/PD study designs by: > -- run 200 simulations with the final model (develope from original > dataset) > -- fit the final model to the 200 simulated dataset > To achieve above, I used $SIM SUBPROB=200 option > however, nonmem would completely stop after running > into estimation problem at one specific simulation/estimation cycles, for > some designs it stop even before 10th iterations. > Is there anyway nonmem could continue go on? > Or, does someone know alternative way to achieve the goal? > thanks > > >
