Dear Ethan, the simplest solution to solve your problem would be to use the bootstrap command of PSN (http://psn.sourceforge.net/). With PSN installed you would simply do:
bootstrap final_model.mod -samples=200 PSN would take care of unsuccessful runs and provide a nice summary of the individual estimates. Best regards Sebastian On Thu, Feb 5, 2009 at 11:18 PM, Ethan Wu <ethan.w...@yahoo.com> wrote: > Dear users, > I am trying to compare several specific PK/PD study designs by: > -- run 200 simulations with the final model (develope from original > dataset) > -- fit the final model to the 200 simulated dataset > To achieve above, I used $SIM SUBPROB=200 option > however, nonmem would completely stop after running > into estimation problem at one specific simulation/estimation cycles, for > some designs it stop even before 10th iterations. > Is there anyway nonmem could continue go on? > Or, does someone know alternative way to achieve the goal? > thanks > > >
