Yaming, For details, I'd refer you to the abstracts, I've never published this. But, whenever I do a bootstrap I look at whether the samples that had a successful covariance step are different (in mean or variability), just for my own interest. They never have been different, I'd guess I've looked at 6 or so. I have no records of what fraction of samples had a successful covariance step. I'd also refer to any number of good reference on how to decide if a model is "good" (plots, biological plauability, reasonable parameters, various metrics of "goodness". etc. I'd suggest that if your parameters are poorly defined by the data (e.g., all concentrations near EMAX, unable to define EC50) you'll invariably find that other metrics suggest lack of model goodness. Whether and how successful covariance or minimization fits into this will have to wait until we have a universally accepted metric of model "goodness". I would list CI (based on bootstrap, not $COV) among my metrics of model goodness, I'd even list a successful covariance step among metrics of model goodness - but pretty far down the list. (everything else being equal, I'd prefer a model that has a successful covariance step - of course everything else is never equal). Mark Sale MD Next Level Solutions, LLC www.NextLevelSolns.com 919-846-9185
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- RE: [NMusers] OMEGA selection Mark Sale - Next Level Solutions
- Re: [NMusers] OMEGA selection Nick Holford
- RE: [NMusers] OMEGA selection Ken Kowalski
- RE: [NMusers] OMEGA selection Hang, Yaming
- RE: [NMusers] OMEGA selection Mark Sale - Next Level Solutions