Dear all,
I am working on this pop PK analysis. the objective is, to explore some
covariates on the exposure.
the dataset has rich sampled study, with absorption phase well captured. and
also sparse sampling study with only trough sample, and another sample around
1-2hr after dosing
with rich sample study data, the ka and eta on Ka is well estimated using FOCE
INT method and 1ct 1st order model.
but when with pooled dataset, using the same model and method, eta on Ka is
estimated to be almost 0, the fit to the data from rich sampled study became
little worse on the peak.
Is there way to keep a good estimation of Eta on Ka, which is to make sure
the good capture of Cmax, at least for rich sampled subjects?
with my limited knowledge, I was thinking:
-- fixing Eta on ka with the estimate from rich sample study alone
-- hybrid estimating methods
-- nonparametric method
Any comments will be highly appreciated.
