Hi,
It looks like you are trying to derive the unknown values of KA, CL/F
and V/F from the known values of Tmax, Cmax and AUC (probably obtained
from a non compartmental analysis).
If that is really the case, you will need to know the values of the
half-life of elimination or the slope of elimination Ke to solve for Ka
and V/F (the following solutions assume a one-compartment model with
linear absorption and elimination):
CL/F = Dose/AUC
V/F = (CL/F)/Ke
KA = - (1/tmax)*ln[ exp(-ke*tmax) - (Cmax*V)/(F*dose) ]
If you don't know Ke, you will have to solve for V/F and Ka numerically,
prior to your simulation.
Sebastien
yhb5442387 wrote:
Dear Nmuser:
I would like to do a data simulation .The distributions of the drug
population pharmaockinetics were assumed to be normal.But the profile
that I have got is Tmax, Cmax,and AUC(the means and variances are
already known),instead of Ka,CL,and V. What the $PK modification
should I have to do in the model where the advan2 has been taken in
the $subroutine.
F=1.
Any suggestion would be appreciated.
Yours,ye hong bo
--
??????????,????????????.
????,????????????????????????.????????,
??????
