I don't recall the context in which this was said, but, I remember Stuart Beal saying something to the effect of "the assumption of normality of distributions is not a strict one and that NONMEM works quite well as long as the distributions are relatively symmetrical". I will leave the interpretation to the rest of you.
________________________________ From: [email protected] [mailto:[email protected]] On Behalf Of Ethan Wu Sent: Tuesday, June 01, 2010 10:04 AM To: Ribbing, Jakob; nmusers Subject: Re: [NMusers] distribution assumption of Eta in NONMEM Dear Jakob and all, In this thread, Mats clearly indicated Eta is assumed normal distributed. But, others have said differently. I wonder which statement is correct? ________________________________ From: "Ribbing, Jakob" <[email protected]> To: nmusers <[email protected]> Sent: Tue, June 1, 2010 3:10:44 AM Subject: RE: [NMusers] distribution assumption of Eta in NONMEM Dear all, Dropping in a little late in the game all I can say is this: Shame on all you great minds for reinventing your own wisdom :>) Most of the content in the current thread has already been discussed in an earlier thread: http://www.mail-archive.com/[email protected]/msg01271.html However, this old thread does contain a lot of postings and quite a few which are VERY confusing, so you may want to skip ahead to Matt's posting here: http://www.mail-archive.com/[email protected]/msg01302.html (There are also many other postings which are very useful, but the one above captures the essence with regards to the original question in the current thread) That said I think there are always new learnings in each thread, as people tend to express themselves differently and the original question branch into several new discussion points. So I guess there are never two threads that are exactly alike, even when the usual suspects participate in both. Cheers Jakob ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
