Ann,
RAM could be a problem if you like to run 16 jobs at once. If so, you
may need a 64-bit machine to support more than 4 Gb of RAM.
Leonid
--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566
On 1/26/2011 10:40 AM, Mark Sale - Next Level Solutions wrote:
Ann,
We benchmarked 32 bit vs 64 bit Intel fortran with NONMEM a few years
ago, with 64 bit XP - the 64 bit version was 10-20% faster.
NONMEM does not multithread (although the next version will multi
process). IMHO, you get the most for your money with an quad core Intel
i5, it is essentially as fast as the I7, but without multithreading. In
our benchmarks, NONMEM performance correlated well with SPECfp benchmark
(www.spec.org <http://www.spec.org>).
I'd suggest staying away from AMD CPUs, the latest ones are advertised
as 12 core, and they are, they have 12 integer computational units, but
have only 6 floating point units, and they perform less well than i5s.
BTW, if you can wait, the Intel 8 core CPUs are supposed to be out 3rd
quarter.
Mark
Mark Sale MD
President, Next Level Solutions, LLC
www.NextLevelSolns.com <http://www.NextLevelSolns.com>
919-846-9185
A carbon-neutral company
See our real time solar energy production at:
http://enlighten.enphaseenergy.com/public/systems/aSDz2458
-------- Original Message --------
Subject: [NMusers] High spec PC setup for NONMEM - recommendations?
From: Ann Rigby-Jones <[email protected]
<mailto:[email protected]>>
Date: Wed, January 26, 2011 9:42 am
To: "[email protected] <mailto:[email protected]>"
<[email protected] <mailto:[email protected]>>
Dear NMUsers
We are investigating the purchase of a hyperthreaded dual quad-core
machine (8 physical cores; hyperthreaded to create 16 logical cores)
with a view to reducing the time taken for those aspects of model
validation that require multiple iterations e.g. bootstrapping,
likelihood profiling. Our current system uses NONMEM 7, with Intel
Fortran running under Windows XP Professional, 32 bit machine . A
licensed version of PLT Tools is used for graphical output and to
facilitate model development and validation.
We are wondering whether a 64bit operating system would be preferred
for optimal performance e.g. 64bit Windows 7? Any comments or
recommendations gratefully received.
With thanks and best wishes
Ann
_______________________________________________________________________
*Ann Rigby-Jones PhD MRSC*
Research Fellow in Pharmacokinetics & Pharmacodynamics
Peninsula College of Medicine & Dentistry
N31, ITTC Phase 1
Tamar Science Park
1 Davy Road
Derriford
Plymouth
PL6 8BX
_______________________________________________________________________
