Hello Robert, Thank you for your help. I figured out the potential reason. I took care of an additive component of the error. It seems like it is wrong to assume that M2-M4 take care of the additive component. It is wrong to assume that the additive component is trivial when M2-M4 are used. Also, the same SD should be used in both the standard and the M2-M4 portions of the objective function.
It will be nice if there is a sorce, which explaines the error messages. The error messages can be puzzeling. Kind regards, Pavel ----- Original Message ----- From: "Bauer, Robert" Date: Thursday, February 10, 2011 7:59 pm Subject: RE: [NMusers] error message 0VAR-COV OF SOME OBS ESTIMATED TO BE 0 - a bug? To: [email protected], Martin Johnson Cc: [email protected] > Pavel: > If you do not mind sharing your control stream file, and if necessary, > your data file (or a truncated version of it), perhaps you could > send it > to me. I may be able to determine if there is a way to modify the > control stream code to avoid these errors, or if there is a bug. > > Robert J. Bauer, Ph.D. > Vice President, Pharmacometrics > ICON Development Solutions > > Tel: (215) 616-6428 > Mob: (925) 286-0769 > Email: [email protected] > Web: www.icondevsolutions.com > > > > > > > > ________________________________ > > From: [email protected] [mailto:owner- > [email protected]]On Behalf Of [email protected] > Sent: Thursday, February 03, 2011 9:32 AM > To: Martin Johnson > Cc: [email protected] > Subject: Re: [NMusers] error message 0VAR-COV OF SOME OBS > ESTIMATED TO > BE 0 - a bug? > > > Thank you Martin, > > It was helpful and educational, but did not resolve the issue. > I just > used a very different code and datasets. The only common part > was > > $EST MAXEVALS=9999 SIG=5 NOABORT PRINT=1 SORT > METHOD=IMP CTYPE=3 NITER=1000 ISAMPLE=300 POSTHOC INTERACTION > > There are no warnings or errors. Newertheless, the code creates > 2 out > of 4 requested output files. Both output files are truncated, i.e. > after a certain subject and a timepoint there are no output > records. It > does not depend on the number of added dummy time points > (MDV=1). What > can it be? > > Thanks, > Pavel > > ----- Original Message ----- > From: Martin Johnson > Date: Friday, January 28, 2011 1:52 am > Subject: Re: [NMusers] error message 0VAR-COV OF SOME OBS > ESTIMATED TO > BE 0 - a bug? > To: [email protected] > > > Dear Pavel, > > Just adding my few cents.. > > I understand that you are very experienced NMUSER, so this > mail > > may not > > add anything new to you. > > > > > > Error message on FNLETA comes from the posthoc step- "An error > > message > > from FNLETA indicates that NONMEM has experienced difficulties > > obtaining posthoc etas" > > Error message on CELS "usually" says that there are some > "zero" > > predictions. > > So, in this way..error message makes some sense... > > > > However, i have not used IMP with M3 and Laplacian, so i can > not > > comment > > on that. > > > > One thing may be...model also tries to predict the pk or pd > for > > zero > > time points...that could cause this problem....if so, CALLFL=0 > > in the > > $ERROR may be of some use > > > > Regards, > > Martin Johnson, > > PhD Student, > > University of Groningen, > > The Netherlands > > > > > > > > On 01/28/2011 12:31 AM, [email protected] wrote: > > > Hello Nonmem Users, > > > > > > I am getting an error message: > > > 0PROGRAM TERMINATED BY FNLETA > > > ERROR IN CELS WITH INDIVIDUAL 2 ID= 1.10050000000000E+01 > > > 0VAR-COV OF SOME OBS ESTIMATED TO BE 0 > > > MESSAGE ISSUED FROM TABLE STEP > > > > > > The estimate step is as follows: > > > $EST MAXEVALS=9999 SIG=5 NOABORT PRINT=1 SORT > > > METHOD=IMP CTYPE=3 NITER=1000 ISAMPLE=300 POSTHOC INTERACTION > > > MSFO=KI4H004D.MSF LAPLACIAN > > > The code also implements M3. The code runs fine, but it does > > not > > > create the output data files specified in the table > > statements. I > > > tried to remove some table statements, changed initial > > esimates, added > > > the additive component to the error model. Nothing helps. > > When I do > > > not use M3 and Laplacian, I am getting the output files. I > > used M3and > > > Laplacian with some other drugs, but I did not use it in > > combination > > > with METHOD=IMP. Can it be a NONMEM bug? The eror does not > > make sense. > > > Thanks, > > > Pavel > > > > > > ICON plc made the following annotations. > ----------------------------------------------------------------- > ------------- > This e-mail transmission may contain confidential or legally > privileged information > that is intended only for the individual or entity named in the > e-mail address. If you > are not the intended recipient, you are hereby notified that any > disclosure, copying, > distribution, or reliance upon the contents of this e-mail is > strictly prohibited. If > you have received this e-mail transmission in error, please > reply to the sender, so that > ICON plc can arrange for proper delivery, and then please delete > the message. > Thank You, > ICON plc > South County Business Park > Leopardstown > Dublin 18 > Ireland > Registered number: 145835 > >
