Dear NonMEM users,
I want to code a two sequential absorption processes with 2 CMT: zero-order
absorption for the first 2.99 hours and then
first-order absorption for the rest time. My code is listed as below. My
question is when I change K0 (zero-order absorpption rate),
the predicted concentrations in the first 2.99 hours does not change. It seems
like AL is useless.
I am very appreciated if anyone can tell me the problem in my code or other
things. Thanks a lot!
$DES
IF (AMT.GT.0) THEN
TDOS=TIME ;dosing time
TL=TDOS+2.99 ;lag time=2.99 hour
ENDIF
AL=0
BL=0
K0=14100
IF (TIME .LE. TDOS) THEN ; for PD baseline
INPT=0
ELSE
IF (TIME .LE. TL .AND.TIME .GT. TDOS ) THEN
AL=1
ELSE
BL=1
ENDIF
ENDIF
INPT=AL*K0+BL*KA*A(1)
C2=A(2)/V1
C3=A(3)/V2
DADT(1) = -INPT
DADT(2) = INPT-CL*C2- CLD*(C2-C3)
DADT(3) = CLD*(C2-C3)
Best regards,
Liu, Dongyang, PhD, Postdoc Fellow
Department of Pharmaceutical sciences,
State University of New York at Buffalo.
Tel(o):01-716-645-4840,
Cell: 01-716-908-6644,
