2011/4/6 Liu Dongyang <[email protected]>
> Dear NonMEM users, > > I want to code a two sequential absorption processes with 2 CMT: > zero-order absorption for the first 2.99 hours and then > first-order absorption for the rest time. My code is listed as below. My > question is when I change K0 (zero-order absorpption rate), > the predicted concentrations in the first 2.99 hours does not change. It > seems like AL is useless. > I am very appreciated if anyone can tell me the problem in my code or > other things. Thanks a lot! > > $DES > > IF (AMT.GT.0) THEN > TDOS=TIME ;dosing time > TL=TDOS+2.99 ;lag time=2.99 hour > ENDIF > > AL=0 > BL=0 > K0=14100 > > IF (TIME .LE. TDOS) THEN ; for PD baseline > INPT=0 > ELSE > IF (TIME .LE. TL .AND.TIME .GT. TDOS ) THEN > AL=1 > ELSE > BL=1 > ENDIF > ENDIF > > INPT=AL*K0+BL*KA*A(1) > > C2=A(2)/V1 > C3=A(3)/V2 > > DADT(1) = -INPT > DADT(2) = INPT-CL*C2- CLD*(C2-C3) > DADT(3) = CLD*(C2-C3) > > > Best regards, > > Liu, Dongyang, PhD, Postdoc Fellow > Department of Pharmaceutical sciences, > State University of New York at Buffalo. > Tel(o):01-716-645-4840, > Cell: 01-716-908-6644, >
