If you are using NONMEM 7.2, IMAX can be increased by setting MAXFCN, by inserting as the first executable line in the control stream file:
$SIZES MAXFCN=1000000000 Keep in mind that as a 4 byte integer, MAXFCN cannot exceed 2**31=2147483648. Robert J. Bauer, Ph.D. Vice President, Pharmacometrics ICON Development Solutions Tel: (215) 616-6428 Mob: (925) 286-0769 Email: [email protected] Web: www.icondevsolutions.com -----Original Message----- From: [email protected] [mailto:[email protected]] On Behalf Of Wenjun Sent: Wednesday, June 22, 2011 4:53 PM To: Li Li Cc: [email protected] Subject: Re: [NMusers] How to Increase Maximum NO. of Evaluations of Differential Equation in NONMEM 7 Dear lili, You can try following code: " FIRST " USE PRCOM_INT,ONLY:MITER,METH,IMAX,ISTFLG,INTFLG " MAIN " IMAX=10000000000000 Hope it helps. Wenjun Ni, Ph.D. Division of Pharmaceutics College of Pharmacy The Ohio State University 500 W 12th Ave Columbus, OH 43210 On Wed, Jun 22, 2011 at 4:17 PM, Li Li <[email protected]> wrote: > Hi, > > I am using ADVAN 6 to do some PKPD modeling and got this error message: > NUMERICAL DIFFICULTIES WITH INTEGRATION > ROUTINE. > MAXIMUM NO. OF EVALUATIONS OF DIFFERENTIAL EQUATIONS, 1000000, > EXCEEDED. > > I know in NONMEM 6 you may use following code to increase maximum number of > integration of differential equation: > "FIRST > " COMMON /PRCOMG/ IDUM1,IDUM2,IMAX,IDUM4,IDUM5 > " INTEGER IDUM1,IDUM2,IMAX,IDUM4,IDUM5 > " IMAX=100000000 > But in NONMEM 7 it gave error message: > (WARNING 113) VERBATIM CODE CONTAINS "COMMON". IF THIS IS NOT A > USER-DEFINED COMMON, IT SHOULD BE REPLACED BY THE APPROPRIATE MODULE. > CREATING MUMODEL ROUTINE... > > Thus, how can I increase maximum number of integration of differential > equation in NONMEM 7? > > Thank you. > > lili ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
