Hello all: After working with Paolo Denti and Sven Stodtman, it has been determined that the occasional spurious CWRES and CWRESI values occurs during parallelization of the diagnostic evaluation step. The best work-around is to set the PARAFILE=OFF option on the first $TABLE record:
$TABLE … PARAFILE=OFF This will allow $EST and $COV step to continue to be parallelized. Single CPU runs will of course not have this issue. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 [email protected]<mailto:[email protected]> www.iconplc.com<http://www.iconplc.com/> From: [email protected] [mailto:[email protected]] On Behalf Of Paolo Denti Sent: Thursday, November 16, 2017 1:34 AM To: nmusers Subject: [NMusers] Extreme values of CWRESI in NONMEM 7.4.1? Dear all, I am reporting about a suspicious behaviour I am observing with CWRESI in NONMEM 7.4.1. I have a patent/metabolite model which fits the data decently in terms of VPCs and other diagnostics, but the CWRESI have some EXTREME values (e.g. some are less than -15 and more than +40). After checking for outliers or mistakes in the dataset and finding no obvious reason for this, I realised something funny was happening. For all those patients with extreme CWRESI values, all the CWRESI were exactly the same as WRES. I noticed that this happened for other subjects as well, without extreme values. In fact it was observed in a number of consecutive patients in the dataset, then the CWRESI and WRES were different once again for a number of IDs, then different again. I pasted below the beginning of my output table (I hope it won't get horribly mangled in the email). You can see for ID 1002 things are fine, but for the next subject, all CWRESI and WRES are 100% the same, which I find very odd. Going on in the table, one then encounters the crazy values (e.g. +40) in those patients where CWRESI=WRES. After thinking that I had messed up something in the code (although I have a fairly standard $ERR chunk), I reran the same models with NM 7.3 and no extreme CWRESI were to be seen and in no patient CWRESI=WRES. I tried ifortran and gfortran, same results. Not sure if this is a bug or something has changed in the implementation of CWRESI in the new version? Anything that needs to be added into the code? Did anyone else experience something similar? Thanks for sharing your experience, Paolo <br /><br /> ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
