Senior Scientist, Clinical Pharmacology/Pharmacometrics
Biogen, US-MA-Cambridge
The Senior Scientist, Clinical Pharmacologist is responsible for the clinical 
pharmacology and pharmacometric deliverable for clinical development assets 
from phase 1-III.
Job Category
Research & Development
Requisition Number
Job Description
The responsibility include to develop a clinical pharmacology plans and dose 
selection and prediction using mathematical and statistical models to study 
complex interactions between drug and patients, between biological systems and 
to understand disease progression and impact of patient stratification on 
disease progression. He/She contributes to evaluating various clinical 
pharmacology and modeling strategies and building clinical pharmacology and 
pharmacometrics infrastructure. The Senior Scientist, clinical pharmacology 
serve as Clinical Pharmacology Lead on programs with high quantitative 
intensity and will collaborate closely with Clinical Pharmacology on advanced 
pharmacology models. Under supervision drives the development and execution of 
the Quantitative Pharmacology and Pharmacometric Strategy of clinical 
development teams. Also support regulatory responses related to clinical 
pharmacology and pharmacometrics. Performs advanced quantitative pharmacology 
and pharmacometric analyses and activities within assigned programs to yield 
high value PK/PD support for critical decisions and dose selection. Interprets 
and presents results and recommends appropriate actions. Develops and maintains 
strong knowledge of best regulatory practices, clinical pharmacology 
principles, PK/PD analysis methodology and drug development precedent. Develops 
and maintains scientific awareness and presence in Quantitative Pharmacology 
and Pharmacometric Science, publishes manuscripts and posters, presents at 
Scientific Conferences and other scientific forums.
Minimum of 3 years (PhD) or 5 years (MSc) of experience working as a clinical 
pharmacologist, DMPK or pharmacometrician within pharmaceutical industry. 
Experience in developing advanced PK/PD models to aid in research and 
development decision making. Knowledge of Health Authority perspective on 
clinical pharmacology and use of modeling and simulation.Strong English oral 
and written communication skills. Employs a continuous improvement in knowledge 
and practical understanding of clinical pharmacology and pharmacometrics 
principles and applies this knowledge in a program team setting.
PhD degree in clinical pharmacology, pharmacy, biomedical engineering, 
statistics, applied mathematics, or a related field. A MSc degree with relevant 
experience is also acceptable.
Please, apply at<> or email


Ivan Nestorov, PhD
Sr. Director, Pharmacometrics
Biogen Inc
225 Binney Street
Cambridge, Massachusetts 02142
Tel: 617-679-2541

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