Hi Leonid, Thanks for the tips. When you talk about Methods, are you referring to different ADVANs? e.g. FOCEI ADVAN6 vs. IMP ADVAN6.
Mark On Wed, Sep 23, 2020 at 5:52 PM Leonid Gibiansky <lgibian...@quantpharm.com> wrote: > > Within one method, FOCEI or IMP models can be compared by OF, but not > between methods. FOCEI and IMP OF are similar by the order of magnitude, > but should not be used for comparison between methods. > > SAEM OF should not be used for model comparison at all. Among two models > that differ by SAEM OF, the one with the higher OF may have better fit > (meaning, lower FOCEI or IMP OF than the other model with lower SAEM OF). > > So if you would like to compare models obtained by different methods, > you may re-run both of them with fixed parameters using the same method > (not SAEM), and then compare obtained OF values. > > Leonid > > > > On 9/23/2020 8:09 PM, Mark Tepeck wrote: > > Hi NMusers, > > > > I believe below is a very common question, but I could not find a > > clear answer in literature. > > > > Sometimes, we want to find out which algorithm offers the better model > > fitting for a given dataset. > > > > Is it possible to use the objective function value (OFV) to compare > > the model fitting computed by various algorithms (e.g. FOCE, IMP, and > > SAEM) ? Put it into another way, the same input dataset with the same > > fitted model/estimates will lead to similar OFVs among FOCE, IMP, and > > SAEM? > > > > > > Thanks, > > > > > > Mark > >
