Dear Shankar, I think you will need to go deeper into the configuration and settings, as well as to the directories where NONMEM was actually run, to answer this question.
Here are some things that you can consider: Did you run both PsN versions using the same nonmem version? If termination was not successful, was PsN (execute) set up to try again with another set of initial estimates, and if it was: did you use the same seed when running execute-4.8 and execute-4.9? The control streams created by PsN (located in the NM_run1 directory): are they identical? In this directory you will find e.g. psn.mod. If on a LINUX system you can just run diff or ’sdiff -s’ to compare this file between the two runs with execute Did you change anything else in the configuration of PsN or NONMEM, e.g. the compiler? Best wishes Jakob Jakob Ribbing, Ph.D. Senior Consultant, Pharmetheus AB Cell/Mobile: +46 (0)70 514 33 77 [email protected] www.pharmetheus.com Phone, Office: +46 (0)18 513 328 Uppsala Science Park, Dag Hammarskjölds väg 36B SE-752 37 Uppsala, Sweden > On 3 May 2021, at 18:45, Shankar Lanke <[email protected]> wrote: > > Dear NMUsers, > I am having trouble with PSN4.9, if anyone has a similar issue may I know how > to fix it? > I ran a model that was developed prior to the release of PSN4.9. In PSN4.9 > the covariance step is aborted because S Matrix is unobtainable. I purged 4.9 > and loaded 4.8, the model ran perfectly and matched the previous results. > Thank you very much in advance. > > Version 4.9 > #TERE: > Elapsed estimation time in seconds: 633.22 > 0S MATRIX UNOBTAINABLE > 0COVARIANCE STEP ABORTED > Elapsed covariance time in seconds: 47.98 > Elapsed postprocess time in seconds: 51.79 > > Version 4.8 > #TERM: > 0MINIMIZATION SUCCESSFUL > NO. OF FUNCTION EVALUATIONS USED: 783 > NO. OF SIG. DIGITS IN FINAL EST.: 2.0 > > Regards, <> > Shankar Lanke -- *This communication is confidential and is only intended for the use of the individual or entity to which it is directed. It may contain information that is privileged and exempt from disclosure under applicable law. If you are not the intended recipient please notify us immediately. Please do not copy it or disclose its contents to any other person.*
