Dear Jakob, 1. Did you run both PsN versions using the same nonmem version? *Yes* 2. If termination was not successful, was PsN (execute) set up to try again with another set of initial estimates *[Yes, tried with different IEs, Fixed few, all combinations]*, and if it was: did you use the same seed when running execute-4.8 and execute-4.9? *Yes* 3. ’sdiff -s’ to compare this file between the two runs with execute- *Yes* 4. Did you change anything else in the configuration of PsN or NONMEM, e.g. the compiler? *Computing system is located in Linux server, I dont think if IT makes any changes to it without informing us, but I will check with them. *
Thank you so much for your time and input. On Tue, May 4, 2021 at 8:58 AM Jakob Ribbing <[email protected]> wrote: > Dear Shankar, > > I think you will need to go deeper into the configuration and settings, as > well as to the directories where NONMEM was actually run, to answer this > question. > > Here are some things that you can consider: > > - Did you run both PsN versions using the same nonmem version? > - If termination was not successful, was PsN (execute) set up to try > again with another set of initial estimates, and if it was: did you use the > same seed when running execute-4.8 and execute-4.9? > - The control streams created by PsN (located in the NM_run1 > directory): are they identical? In this directory you will find e.g. > psn.mod. If on a LINUX system you can just run diff or ’sdiff -s’ to > compare this file between the two runs with execute > - Did you change anything else in the configuration of PsN or NONMEM, > e.g. the compiler? > > > Best wishes > > Jakob > > > > Jakob Ribbing, Ph.D. > > Senior Consultant, Pharmetheus AB > > > Cell/Mobile: +46 (0)70 514 33 77 > > [email protected] > > www.pharmetheus.com > > Phone, Office: +46 (0)18 513 328 > > Uppsala Science Park, Dag Hammarskjölds väg 36B > SE-752 37 Uppsala, Sweden > > > > > On 3 May 2021, at 18:45, Shankar Lanke <[email protected]> wrote: > > Dear NMUsers, > I am having trouble with PSN4.9, if anyone has a similar issue may I know > how to fix it? > I ran a model that was developed prior to the release of PSN4.9. In PSN4.9 > the covariance step is aborted because S Matrix is unobtainable. I purged > 4.9 and loaded 4.8, the model ran perfectly and matched the > previous results. Thank you very much in advance. > > > *Version 4.9* > #TERE: > Elapsed estimation time in seconds: 633.22 > 0S MATRIX UNOBTAINABLE > 0COVARIANCE STEP ABORTED > Elapsed covariance time in seconds: 47.98 > Elapsed postprocess time in seconds: 51.79 > > > *Version 4.8* > #TERM: > 0MINIMIZATION SUCCESSFUL > NO. OF FUNCTION EVALUATIONS USED: 783 > NO. OF SIG. DIGITS IN FINAL EST.: 2.0 > > > Regards, > Shankar Lanke > > > > *This communication is confidential and is only intended for the use of > the individual or entity to which it is directed. It may contain > information that is privileged and exempt from disclosure under applicable > law. If you are not the intended recipient please notify us immediately. > Please do not copy it or disclose its contents to any other person.* > -- Regards, Shankar Lanke Ph.D.
