Dear all, I wonder if anyone has experience with the error of illegal division by 0 when running PsN SCM with continuous time-varying covariates (error message in below). The same scm command and configuration file works perfectly fine for categorical covariates. F:1 .. Illegal division by zero at C:/GBW_MyPrograms/PsN-5.3.0/strawberry/perl/bin/..\site\lib\PsN_5_3_0/tool/scm.pm line 6246.
Upon inspection, it appears that the error stems from the variable $CIWRESI becoming zero (line 6246 in below). my $W = ($DV - $CIPREDI) / $CIWRESI; My NONMEM code is in below. Any thoughts on how to solve this? $ERROR IPRED = F IRES = DV - IPRED W = SQRT((THETA(5)*IPRED)**2 + THETA(6)**2) IF (W.EQ.0) W = 1 IWRES = IRES/W LLOQ=0.1 IF (DV.GE.LLOQ) THEN F_FLAG = 0 Y = IPRED + EPS(1)*W ELSE F_FLAG = 1 Y = PHI((LLOQ-IPRED)/W) ENDIF IF (ICALL.EQ.4) THEN Y = IPRED + EPS(1)*W END IF Thank you! Zhigang ------------------------------------------------------------ Zhigang Wang, MSc, PhD candidate Leuven Pharmacometrics Research Group Dept. of Pharmaceutical and Pharmacological Sciences KU Leuven, Belgium
