For CV, look for "geometric CV" here:
https://en.wikipedia.org/wiki/Coefficient_of_variation
(Sln^2 in Nonmem OMEGA).
Or you can use simpler (but approximate) expression
CV%=100*SQRT(OMEGA).
For RSE, not sure. Nonmem reports OMEGA SE that can be used to compute
OMEGA CI (confidence intervals), than can be translated to CI for CV (if
needed) as described above.
Leonid
On 5/11/2024 10:08 AM, Anita Moein wrote:
Dear All:
I have a question regarding reporting ETAs as %CV instead of variance.
In NONMEM the IIV estimate is reported as variance with associated RSE%.
How can I convert the IIV Estimate and RSE% to report it as CV%?
Thank you!
Best,
Anita
*Anita Moein*
Senior Scientist
Modeling and Simulation | Clinical Pharmacology | Genentech
Phone: (650) 866 7701 | Cell: (415) 254 7972
