Dear Anita,
You can find all details in {shameless plug} our PSP tutorial on
log-normal variability:
https://ascpt.onlinelibrary.wiley.com/doi/full/10.1002/psp4.12507
or go straight to the cheatsheet
https://ascpt.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fpsp4.12507&file=psp412507-sup-0002-TableS1.pdf
from there you get the CV as
sqrt(exp(OMEGA)-1) .
The SE is usually approximated as SE/OMEGA/2
The above is assuming the usual expression of PARM =
THETA(x)*EXP(ETA(y)) and OMEGA for the variance estimate.
Hope this helps,
Jeroen
http://pd-value.com
[email protected]
@PD_value
+31 6 23118438
-- More value out of your data!
On 11-05-2024 16:08, Anita Moein wrote:
Dear All:
I have a question regarding reporting ETAs as %CV instead of variance.
In NONMEM the IIV estimate is reported as variance with associated RSE%.
How can I convert the IIV Estimate and RSE% to report it as CV%?
Thank you!
Best,
Anita
*Anita Moein*
Senior Scientist
Modeling and Simulation | Clinical Pharmacology | Genentech
Phone: (650) 866 7701 | Cell: (415) 254 7972
