The link still works, but there are sometimes security filters that prevent successful connection. Access the link first:
https://nonmem.iconplc.com/nonmem_history Then click on the nonmem_history4.pdf file for the download. Clarifying one item in Douglas Elevald's e-mail : Rights were obtained by ICON Plc as of NONMEM VI, and NONMEM 7.1 was the first version in which code was encrypted. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 731 Arbor way, suite 100 Blue Bell, PA 19422 Office: (215) 616-6428 Mobile: (925) 286-0769 robert.ba...@iconplc.com<mailto:robert.ba...@iconplc.com> www.iconplc.com<http://www.iconplc.com/> From: owner-nmus...@globomaxnm.com <owner-nmus...@globomaxnm.com> On Behalf Of Bonate, Peter Sent: Wednesday, December 4, 2024 6:42 AM To: Eleveld, DJ <d.j.elev...@umcg.nl>; nmusers <nmusers@globomaxnm.com> Subject: [EXTERNAL] [NMusers] RE: Historical question Personally I don't think it was the use of FOCEI that led to NONMEM taking off, it was that you could run it on personal computers, which were just starting to be powerful enough to handle to computational load. This was back when computers had numbers for names, like 386 and 486. I think this started with NONMEM IV. There was a history of NONMEM webpage that Icon maintained, but when I checked today, it no longer looks like it is functional. https://nonmem.iconplc.com/nonmem_history/NONMEM_history4.pdf<https://nonmem.iconplc.com/nonmem_history/NONMEM_history4.pdf> Pete Bonate Peter Bonate, PhD Suzerain, New Technologies Early Development Astellas 2375 Waterview Drive Northbrook, IL 60062 peter.bon...@astellas.com<mailto:peter.bon...@astellas.com> (224) 619-4901 From: owner-nmus...@globomaxnm.com<mailto:owner-nmus...@globomaxnm.com> <owner-nmus...@globomaxnm.com<mailto:owner-nmus...@globomaxnm.com>> On Behalf Of Eleveld, DJ Sent: Wednesday, December 4, 2024 5:39 AM To: nmusers <nmusers@globomaxnm.com<mailto:nmusers@globomaxnm.com>> Subject: [NMusers] Historical question Hi All, I am writing a paper on some C language code I have written that does FOCE. I want to write a few sentences about the history of NONMEM but I'm not 100% sure it is correct. Can someone knowledgeable give me some feedback on this? Hi All, I am writing a paper on some C language code I have written that does FOCE. I want to write a few sentences about the history of NONMEM but I'm not 100% sure it is correct. Can someone knowledgeable give me some feedback on this? "NONMEM software was developed at USCF in the late 1970s and became the de-facto industry standard when the first-order-conditional estimation with interaction (FOCE-I) method reaching wide use in the field. NONMEM was open source until version 5 when the rights were obtained by Icon PLC and it became encrypted-source. The investment of Icon PLC has resulted in considerable NONMEM development with many bug-fixes and new features available in current version 7.5.1. " Warm regards, Douglas Eleveld ________________________________ De inhoud van dit bericht is vertrouwelijk en alleen bestemd voor de geadresseerde(n). Anderen dan de geadresseerde(n) mogen geen gebruik maken van dit bericht, het niet openbaar maken of op enige wijze verspreiden of vermenigvuldigen. Het UMCG kan niet aansprakelijk gesteld worden voor een incomplete aankomst of vertraging van dit verzonden bericht. The contents of this message are confidential and only intended for the eyes of the addressee(s). Others than the addressee(s) are not allowed to use this message, to make it public or to distribute or multiply this message in any way. The UMCG cannot be held responsible for incomplete reception or delay of this transferred message. <br /><br /> ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
