I've not directly heard of cases, but I'm not sure of many doing it.

How to address disk space issues that are caused by a large Windows component store (WinSxS) directory:
http://support.microsoft.com/kb/2795190/en-us
More links from MS regarding WinSxS

On 12/5/2013 9:55 AM, Micheal Espinola Jr wrote:
Hi Susan!

While you're here, and this doesn't relate to patch-management directly - do you know of any negative repercussions to compressing parts of, if not all of the WinSXS folder structure?

--
Espi


On Thu, Dec 5, 2013 at 9:33 AM, Susan Bradley <[email protected] <mailto:[email protected]>> wrote:

    Not to mention if the WinSXS folder is not cleaned up in the
    manner that Windows wants it to be cleaned up you can render your
    machine unpatchable and be facing a repair install (at best) and
    total rebuild at worst.

    
http://blogs.technet.com/b/joscon/archive/2010/08/06/should-you-delete-files-in-the-winsxs-directory-and-what-s-the-deal-with-vss.aspx
    
http://blogs.technet.com/b/joscon/archive/2009/06/12/why-is-the-windows-winsxs-directory-so-large.aspx

    Even if it's not malware, I would not be using a tool that isn't
    blessed and supported by Mothership Redmond.
    (lurker on the list/listmom on Patch management.org
    <http://management.org> where there's enough patching pain caused
    by update without inflicting more on yourself)


    On 12/5/2013 9:14 AM, Richard Stovall wrote:

        Does Amit still have his world-renowned malware testing lab?
         Maybe he could check it out for us.


        On Thu, Dec 5, 2013 at 11:36 AM, Ben Scott
        <[email protected] <mailto:[email protected]>
        <mailto:[email protected] <mailto:[email protected]>>>
        wrote:

              Fellow list members: Poster of the below has never
        posted to this
            list before.  This is, at best, spam.  Software may even
        be a trojan
            horse.

              OP: If you are legit, my apologies, but this behavior is
        highly
            suspicious.

            On Thu, Dec 5, 2013 at 11:25 AM, Arma Rayo
        <[email protected] <mailto:[email protected]>
            <mailto:[email protected]
        <mailto:[email protected]>>> wrote:
            > A lot of people are having frustration with WinSxs
        folder and
            especially
            > with it's ever-growing size.
            >
            > MS has released an update to Disk Cleanup that can help to
            reduce the size
            > of the folder by removing SP backups and it's backups.
            >
            > However for many this is not enough.
            >
            > A Chinese based coder group has launched a tool called
            >
            > The Windows Update Clean Tool
            >
            > PIC
            > http://ejie.me/images/win_upd_clean.png
            >
            > The tool is very careful and precise and only deletes
        what is
            safe to
            > delete. It also links/junctions old deleted items to the
        latest
            ones. Be
            > noted that cleaning WinSxs with this tool: Rolling back
        Windows
            Updates
            > isn't possible.
            >
            > Always use the latest version, DOWNLOAD link here:
            > http://www.chuyusoft.com/thread-274-1-1.html
            >
            > CHEERS




-- Got your CryptoLocker prevention in place?
    http://www.thirdtier.net/2013/10/cryptolocker-prevention-kit-updates/





--
Got your CryptoLocker prevention in place?
http://www.thirdtier.net/2013/10/cryptolocker-prevention-kit-updates/



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